Histopathological and immunological investigations of synthetic fibres and structures used in three prosthetic anterior cruciate ligaments

in vivo study in the rat

Yves Marois, Raynald Roy, Tamas J Vidovszky, Martin W. King, Alain Y. Bélanger, Cyril Chaput, Robert Guidoin

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Three types of prosthetic anterior cruciate ligaments were investigated by enzymatic and histological analysis of the tissue surrounding each implant and immunologically by a cytofluorometric analysis of T-cell populations in the peripheral blood of rats. Two of the prostheses had a braided construction, one made from polyester and the other from high performance polyethylene fibres. The third type also contained high performance polyethylene fibres, but had been manufactured in a knitted construction (Raschel high performance polyethylene). Five specimens from each prosthesis were implanted intraperitoneally in rats by a trocar for different periods of time up to 4 wk. A control group of rats underwent the surgery, but not the implant. No modification in peripheral T-cell populations was induced by the presence of any implant. Whilst the levels of acid phosphatase and esterase activity appeared to have increased slightly following implantation of any of the prostheses, such increases were not highly significant. Histologically, all three materials induced an intense acute inflammatory reaction at 3 d which gave way to a typical chronic response after 4 wk. The only major difference between the prostheses was that after 4 wk the polyester fibres exhibited less inflammation, and the surrounding tissue was more mature, more vascularized and more densely infiltrated with collagen than with the two high performance polyethylene implants. In conclusion, all three devices provided satisfactory biocompatibility in terms of cellular and healing response.

Original languageEnglish (US)
Pages (from-to)255-262
Number of pages8
JournalBiomaterials
Volume14
Issue number4
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Synthetic fibers
Anterior Cruciate Ligament
Ligaments
Polyethylene
Prosthetics
Polyethylenes
Rats
Prostheses and Implants
Polyesters
T-cells
Fibers
Prosthesis Implantation
Tissue
Acetylesterase
T-Lymphocytes
Phosphatases
Acid Phosphatase
Biocompatibility
Surgical Instruments
Collagen

Keywords

  • acid phosphatase
  • polyethylene
  • Prosthetic ligaments
  • T-cell populations

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

Histopathological and immunological investigations of synthetic fibres and structures used in three prosthetic anterior cruciate ligaments : in vivo study in the rat. / Marois, Yves; Roy, Raynald; Vidovszky, Tamas J; King, Martin W.; Bélanger, Alain Y.; Chaput, Cyril; Guidoin, Robert.

In: Biomaterials, Vol. 14, No. 4, 1993, p. 255-262.

Research output: Contribution to journalArticle

Marois, Yves ; Roy, Raynald ; Vidovszky, Tamas J ; King, Martin W. ; Bélanger, Alain Y. ; Chaput, Cyril ; Guidoin, Robert. / Histopathological and immunological investigations of synthetic fibres and structures used in three prosthetic anterior cruciate ligaments : in vivo study in the rat. In: Biomaterials. 1993 ; Vol. 14, No. 4. pp. 255-262.
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