Abstract
PURPOSE: This study observes the histologic changes resulting from a hydrogel embolic agent (polyacrylonitrile [PAN]) compared with polyvinyl alcohol particles (PVA) of similar size. MATERIALS AND METHODS: Hepatic and renal embolizations were performed in 13 domestic swine by selecting small (1-mm) branches utilizing a coaxial 3-F microcatheter. The hydrogel embolie agent (tantalum-loaded and plain) and PVA were delivered through microcatheters. The longest follow-up period was 8 weeks. Postmortem examination of the embolized tissues included gross examination and histologic analysis. RESULTS: Tantalum-loaded PAN particles were radiopaque and seen in groups fluoroscopically and individually with specimen radiography. Histologic studies showed similar luminal and cellular response to PVA and the hydrogel embolie agents. The arterial lesion induced by the hydrogel embolie agents led to an absence of the arterial wall locally in the area of deployment. Hydrogel embolie particles became surrounded in fibrous connective tissue with no arterial wall. PVA and porous hydrogel capsules produced an inflammatory response, resulting in less wall reorganization, and surrounding fibrous connective tissue at 8 weeks than the solid PAN particles. CONCLUSION: These hydrogel emboli create a permanent arterial occlusion by transmural arterial damage. Mechanical effects and, to a lesser degree, inflammatory changes are responsible.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 897-905 |
| Number of pages | 9 |
| Journal | Journal of Vascular and Interventional Radiology |
| Volume | 7 |
| Issue number | 6 |
| State | Published - 1996 |
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Keywords
- Arteries, therapeutic blockade
- Interventional procedures, experimental
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Histopathologic appearance of arterial occlusions with hydrogel and polyvinyl alcohol embolic material in domestic swine. / Link, Daniel P; Strandberg, John D.; Virmani, Renu; Blashka, Ken; Mourtada, Firas; Samphilipo, Michael A.
In: Journal of Vascular and Interventional Radiology, Vol. 7, No. 6, 1996, p. 897-905.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Histopathologic appearance of arterial occlusions with hydrogel and polyvinyl alcohol embolic material in domestic swine
AU - Link, Daniel P
AU - Strandberg, John D.
AU - Virmani, Renu
AU - Blashka, Ken
AU - Mourtada, Firas
AU - Samphilipo, Michael A.
PY - 1996
Y1 - 1996
N2 - PURPOSE: This study observes the histologic changes resulting from a hydrogel embolic agent (polyacrylonitrile [PAN]) compared with polyvinyl alcohol particles (PVA) of similar size. MATERIALS AND METHODS: Hepatic and renal embolizations were performed in 13 domestic swine by selecting small (1-mm) branches utilizing a coaxial 3-F microcatheter. The hydrogel embolie agent (tantalum-loaded and plain) and PVA were delivered through microcatheters. The longest follow-up period was 8 weeks. Postmortem examination of the embolized tissues included gross examination and histologic analysis. RESULTS: Tantalum-loaded PAN particles were radiopaque and seen in groups fluoroscopically and individually with specimen radiography. Histologic studies showed similar luminal and cellular response to PVA and the hydrogel embolie agents. The arterial lesion induced by the hydrogel embolie agents led to an absence of the arterial wall locally in the area of deployment. Hydrogel embolie particles became surrounded in fibrous connective tissue with no arterial wall. PVA and porous hydrogel capsules produced an inflammatory response, resulting in less wall reorganization, and surrounding fibrous connective tissue at 8 weeks than the solid PAN particles. CONCLUSION: These hydrogel emboli create a permanent arterial occlusion by transmural arterial damage. Mechanical effects and, to a lesser degree, inflammatory changes are responsible.
AB - PURPOSE: This study observes the histologic changes resulting from a hydrogel embolic agent (polyacrylonitrile [PAN]) compared with polyvinyl alcohol particles (PVA) of similar size. MATERIALS AND METHODS: Hepatic and renal embolizations were performed in 13 domestic swine by selecting small (1-mm) branches utilizing a coaxial 3-F microcatheter. The hydrogel embolie agent (tantalum-loaded and plain) and PVA were delivered through microcatheters. The longest follow-up period was 8 weeks. Postmortem examination of the embolized tissues included gross examination and histologic analysis. RESULTS: Tantalum-loaded PAN particles were radiopaque and seen in groups fluoroscopically and individually with specimen radiography. Histologic studies showed similar luminal and cellular response to PVA and the hydrogel embolie agents. The arterial lesion induced by the hydrogel embolie agents led to an absence of the arterial wall locally in the area of deployment. Hydrogel embolie particles became surrounded in fibrous connective tissue with no arterial wall. PVA and porous hydrogel capsules produced an inflammatory response, resulting in less wall reorganization, and surrounding fibrous connective tissue at 8 weeks than the solid PAN particles. CONCLUSION: These hydrogel emboli create a permanent arterial occlusion by transmural arterial damage. Mechanical effects and, to a lesser degree, inflammatory changes are responsible.
KW - Arteries, therapeutic blockade
KW - Interventional procedures, experimental
UR - http://www.scopus.com/inward/record.url?scp=0030279507&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030279507&partnerID=8YFLogxK
M3 - Article
C2 - 8951758
AN - SCOPUS:0030279507
VL - 7
SP - 897
EP - 905
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
SN - 1051-0443
IS - 6
ER -