Histopathologic appearance of arterial occlusions with hydrogel and polyvinyl alcohol embolic material in domestic swine

Daniel P Link, John D. Strandberg, Renu Virmani, Ken Blashka, Firas Mourtada, Michael A. Samphilipo

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

PURPOSE: This study observes the histologic changes resulting from a hydrogel embolic agent (polyacrylonitrile [PAN]) compared with polyvinyl alcohol particles (PVA) of similar size. MATERIALS AND METHODS: Hepatic and renal embolizations were performed in 13 domestic swine by selecting small (1-mm) branches utilizing a coaxial 3-F microcatheter. The hydrogel embolie agent (tantalum-loaded and plain) and PVA were delivered through microcatheters. The longest follow-up period was 8 weeks. Postmortem examination of the embolized tissues included gross examination and histologic analysis. RESULTS: Tantalum-loaded PAN particles were radiopaque and seen in groups fluoroscopically and individually with specimen radiography. Histologic studies showed similar luminal and cellular response to PVA and the hydrogel embolie agents. The arterial lesion induced by the hydrogel embolie agents led to an absence of the arterial wall locally in the area of deployment. Hydrogel embolie particles became surrounded in fibrous connective tissue with no arterial wall. PVA and porous hydrogel capsules produced an inflammatory response, resulting in less wall reorganization, and surrounding fibrous connective tissue at 8 weeks than the solid PAN particles. CONCLUSION: These hydrogel emboli create a permanent arterial occlusion by transmural arterial damage. Mechanical effects and, to a lesser degree, inflammatory changes are responsible.

Original languageEnglish (US)
Pages (from-to)897-905
Number of pages9
JournalJournal of Vascular and Interventional Radiology
Volume7
Issue number6
StatePublished - 1996

Fingerprint

Hydrogel
Swine
Polyvinyl Alcohol
Tantalum
Connective Tissue
Embolism
Particle Size
Radiography
Capsules
polyvinyl alcohol hydrogel
Autopsy
Kidney
Liver
polyacrylonitrile

Keywords

  • Arteries, therapeutic blockade
  • Interventional procedures, experimental

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Link, D. P., Strandberg, J. D., Virmani, R., Blashka, K., Mourtada, F., & Samphilipo, M. A. (1996). Histopathologic appearance of arterial occlusions with hydrogel and polyvinyl alcohol embolic material in domestic swine. Journal of Vascular and Interventional Radiology, 7(6), 897-905.

Histopathologic appearance of arterial occlusions with hydrogel and polyvinyl alcohol embolic material in domestic swine. / Link, Daniel P; Strandberg, John D.; Virmani, Renu; Blashka, Ken; Mourtada, Firas; Samphilipo, Michael A.

In: Journal of Vascular and Interventional Radiology, Vol. 7, No. 6, 1996, p. 897-905.

Research output: Contribution to journalArticle

Link, DP, Strandberg, JD, Virmani, R, Blashka, K, Mourtada, F & Samphilipo, MA 1996, 'Histopathologic appearance of arterial occlusions with hydrogel and polyvinyl alcohol embolic material in domestic swine', Journal of Vascular and Interventional Radiology, vol. 7, no. 6, pp. 897-905.
Link, Daniel P ; Strandberg, John D. ; Virmani, Renu ; Blashka, Ken ; Mourtada, Firas ; Samphilipo, Michael A. / Histopathologic appearance of arterial occlusions with hydrogel and polyvinyl alcohol embolic material in domestic swine. In: Journal of Vascular and Interventional Radiology. 1996 ; Vol. 7, No. 6. pp. 897-905.
@article{7cb7ee20c3984d1caf4ff0cca879908a,
title = "Histopathologic appearance of arterial occlusions with hydrogel and polyvinyl alcohol embolic material in domestic swine",
abstract = "PURPOSE: This study observes the histologic changes resulting from a hydrogel embolic agent (polyacrylonitrile [PAN]) compared with polyvinyl alcohol particles (PVA) of similar size. MATERIALS AND METHODS: Hepatic and renal embolizations were performed in 13 domestic swine by selecting small (1-mm) branches utilizing a coaxial 3-F microcatheter. The hydrogel embolie agent (tantalum-loaded and plain) and PVA were delivered through microcatheters. The longest follow-up period was 8 weeks. Postmortem examination of the embolized tissues included gross examination and histologic analysis. RESULTS: Tantalum-loaded PAN particles were radiopaque and seen in groups fluoroscopically and individually with specimen radiography. Histologic studies showed similar luminal and cellular response to PVA and the hydrogel embolie agents. The arterial lesion induced by the hydrogel embolie agents led to an absence of the arterial wall locally in the area of deployment. Hydrogel embolie particles became surrounded in fibrous connective tissue with no arterial wall. PVA and porous hydrogel capsules produced an inflammatory response, resulting in less wall reorganization, and surrounding fibrous connective tissue at 8 weeks than the solid PAN particles. CONCLUSION: These hydrogel emboli create a permanent arterial occlusion by transmural arterial damage. Mechanical effects and, to a lesser degree, inflammatory changes are responsible.",
keywords = "Arteries, therapeutic blockade, Interventional procedures, experimental",
author = "Link, {Daniel P} and Strandberg, {John D.} and Renu Virmani and Ken Blashka and Firas Mourtada and Samphilipo, {Michael A.}",
year = "1996",
language = "English (US)",
volume = "7",
pages = "897--905",
journal = "Journal of Vascular and Interventional Radiology",
issn = "1051-0443",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Histopathologic appearance of arterial occlusions with hydrogel and polyvinyl alcohol embolic material in domestic swine

AU - Link, Daniel P

AU - Strandberg, John D.

AU - Virmani, Renu

AU - Blashka, Ken

AU - Mourtada, Firas

AU - Samphilipo, Michael A.

PY - 1996

Y1 - 1996

N2 - PURPOSE: This study observes the histologic changes resulting from a hydrogel embolic agent (polyacrylonitrile [PAN]) compared with polyvinyl alcohol particles (PVA) of similar size. MATERIALS AND METHODS: Hepatic and renal embolizations were performed in 13 domestic swine by selecting small (1-mm) branches utilizing a coaxial 3-F microcatheter. The hydrogel embolie agent (tantalum-loaded and plain) and PVA were delivered through microcatheters. The longest follow-up period was 8 weeks. Postmortem examination of the embolized tissues included gross examination and histologic analysis. RESULTS: Tantalum-loaded PAN particles were radiopaque and seen in groups fluoroscopically and individually with specimen radiography. Histologic studies showed similar luminal and cellular response to PVA and the hydrogel embolie agents. The arterial lesion induced by the hydrogel embolie agents led to an absence of the arterial wall locally in the area of deployment. Hydrogel embolie particles became surrounded in fibrous connective tissue with no arterial wall. PVA and porous hydrogel capsules produced an inflammatory response, resulting in less wall reorganization, and surrounding fibrous connective tissue at 8 weeks than the solid PAN particles. CONCLUSION: These hydrogel emboli create a permanent arterial occlusion by transmural arterial damage. Mechanical effects and, to a lesser degree, inflammatory changes are responsible.

AB - PURPOSE: This study observes the histologic changes resulting from a hydrogel embolic agent (polyacrylonitrile [PAN]) compared with polyvinyl alcohol particles (PVA) of similar size. MATERIALS AND METHODS: Hepatic and renal embolizations were performed in 13 domestic swine by selecting small (1-mm) branches utilizing a coaxial 3-F microcatheter. The hydrogel embolie agent (tantalum-loaded and plain) and PVA were delivered through microcatheters. The longest follow-up period was 8 weeks. Postmortem examination of the embolized tissues included gross examination and histologic analysis. RESULTS: Tantalum-loaded PAN particles were radiopaque and seen in groups fluoroscopically and individually with specimen radiography. Histologic studies showed similar luminal and cellular response to PVA and the hydrogel embolie agents. The arterial lesion induced by the hydrogel embolie agents led to an absence of the arterial wall locally in the area of deployment. Hydrogel embolie particles became surrounded in fibrous connective tissue with no arterial wall. PVA and porous hydrogel capsules produced an inflammatory response, resulting in less wall reorganization, and surrounding fibrous connective tissue at 8 weeks than the solid PAN particles. CONCLUSION: These hydrogel emboli create a permanent arterial occlusion by transmural arterial damage. Mechanical effects and, to a lesser degree, inflammatory changes are responsible.

KW - Arteries, therapeutic blockade

KW - Interventional procedures, experimental

UR - http://www.scopus.com/inward/record.url?scp=0030279507&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030279507&partnerID=8YFLogxK

M3 - Article

C2 - 8951758

AN - SCOPUS:0030279507

VL - 7

SP - 897

EP - 905

JO - Journal of Vascular and Interventional Radiology

JF - Journal of Vascular and Interventional Radiology

SN - 1051-0443

IS - 6

ER -