Histone H3.3 Mutations

A Variant Path to Cancer

Benjamin T K Yuen, Paul S Knoepfler

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

A host of cancer types exhibit aberrant histone modifications. Recently, distinct and recurrent mutations in a specific histone variant, histone H3.3, have been implicated in a high proportion of malignant pediatric brain cancers. The presence of mutant H3.3 histone disrupts epigenetic posttranslational modifications near genes involved in cancer processes and in brain function. Here, we review possible mechanisms by which mutant H3.3 histones may act to promote tumorigenesis. Furthermore, we discuss how perturbations in normal H3.3 chromatin-related and epigenetic functions may more broadly contribute to the formation of human cancers.

Original languageEnglish (US)
Pages (from-to)567-574
Number of pages8
JournalCancer Cell
Volume24
Issue number5
DOIs
StatePublished - Nov 11 2013

Fingerprint

Histones
Mutation
Epigenomics
Neoplasms
Histone Code
Post Translational Protein Processing
Brain Neoplasms
Chromatin
Carcinogenesis
Pediatrics
Brain
Genes

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

Cite this

Histone H3.3 Mutations : A Variant Path to Cancer. / Yuen, Benjamin T K; Knoepfler, Paul S.

In: Cancer Cell, Vol. 24, No. 5, 11.11.2013, p. 567-574.

Research output: Contribution to journalArticle

Yuen, Benjamin T K ; Knoepfler, Paul S. / Histone H3.3 Mutations : A Variant Path to Cancer. In: Cancer Cell. 2013 ; Vol. 24, No. 5. pp. 567-574.
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