Histological Subtypes of Oral Non-tonsillar Squamous Cell Carcinoma in Dogs

Research output: Contribution to journalArticle

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Abstract

Several histological subtypes and grades of oral squamous cell carcinoma (SCC) are described in human literature and these subtypes have distinct morphological features and biological behaviour. This retrospective study (1990-2010) included 84 dogs diagnosed with SCC of the oral cavity and oropharynx, excluding the tonsils. Sixty-nine of the SCCs (82.1%) were further diagnosed as conventional SCC (CSCC) (33 [47.8%] well-differentiated, 31 [44.9%] moderately-differentiated and five [7.3%] poorly-differentiated), five (5.95%) each as papillary SCC and basaloid SCC, three (3.6%) as adenosquamous carcinoma and two (2.4%) as spindle cell carcinoma. Compared with the general hospital population, neutered female dogs, dogs aged 10 to <15. years, English springer spaniels and Shetland sheepdogs were overrepresented. The majority (78.1%) of SCCs were proliferative with or without associated ulceration, although no significant association was observed between the gross appearance and different SCC subtypes. 71.4% of SCCs were located in dentate jaws; however, well-differentiated CSCC more often affected the tongue and other non-dentate mucosal surfaces (P= 0.0022). No significant association was found between any of the SCC subtypes and tumour-associated inflammation (TAI), perineural and lymphovascular invasion (PNI, LVI), or between gross appearance of the tumour and tumour location, PNI, LVI or TAI or PNI, LVI, TAI and tumour location.

Original languageEnglish (US)
Pages (from-to)111-120
Number of pages10
JournalJournal of Comparative Pathology
Volume147
Issue number2-3
DOIs
StatePublished - Aug 2012

Fingerprint

squamous cell carcinoma
Squamous Cell Carcinoma
mouth
Dogs
dogs
neoplasms
Neoplasms
inflammation
Inflammation
carcinoma
English Springer Spaniel
Shetland Sheepdog
Adenosquamous Carcinoma
Oropharynx
tonsils
Papillary Carcinoma
Palatine Tonsil
Jaw
tongue
jaws

Keywords

  • Dog
  • Histological subtype
  • Oral squamous cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • veterinary(all)

Cite this

Histological Subtypes of Oral Non-tonsillar Squamous Cell Carcinoma in Dogs. / Nemec, A.; Murphy, Brian G; Kass, Philip H; Verstraete, Frank J.

In: Journal of Comparative Pathology, Vol. 147, No. 2-3, 08.2012, p. 111-120.

Research output: Contribution to journalArticle

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