Histologic and Immunohistochemical Review of Splenic Fibrohistiocytic Nodules in Dogs

A. S. Moore, A. E. Frimberger, N. Sullivan, Peter F Moore

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Background: Splenic fibrohistiocytic nodules (SFHN) are commonly diagnosed. It is suspected that these represent a heterogeneous group of malignant and nonmalignant diseases, separation of which could improve the ability of clinicians to prognosticate for dogs. Hypothesis/Objectives: Immunohistochemistry will differentiate histologic diagnoses within the group of SFHN; survival after splenectomy is associated with those histologic types. Animals: Thirty-two dogs with SFHN treated by or under direction from veterinary oncologists. Methods: Retrospective case record analysis from dogs followed from splenectomy until death. Clinical, histopathologic, and immunohistochemistry data analyzed for an association with survival time. Results: Thirty-two dogs had SFHN; grade 1 (2 dogs), grade 2 (9 dogs), and grade 3 (lymphoid percentage <40%; 21 dogs). Twenty-two dogs died, 10 were censored (9 alive median of 883 days after splenectomy). Median overall survival was 387 days, and grade 3 SFHN was positively associated with survival time as previously reported (P < .001). Of 31 available samples, dogs had diseases reclassified as nodular hyperplasia (13; 8 complex, 5 lymphoid including 2 marginal zone), lymphoma (4; 2 marginal zone lymphoma, 1 high grade B-cell lymphoma, and 1 marginal zone transitional to high grade B-cell lymphoma), 8 stromal sarcomas, and 6 histiocytic sarcomas. Dogs with histiocytic sarcoma had worse survival (median 74 days) than dogs with other diseases. Conclusions and Clinical Importance: Splenic histiocytic sarcoma is an aggressive disease; however, some dogs with stromal sarcomas had long survival times. The term SFHN is no longer warranted for this group of disorders.

Original languageEnglish (US)
Pages (from-to)1164-1168
Number of pages5
JournalJournal of Veterinary Internal Medicine
Issue number5
StatePublished - Sep 2012


  • Cancer
  • Chemotherapy
  • Histiocytic sarcoma
  • Oncology

ASJC Scopus subject areas

  • veterinary(all)


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