Histologic and biochemical differences between osteolytic and nonosteolytic membranes around femoral components of an uncemented total hip arthroplasty

Tamas J Vidovszky, Miguel E. Cabanela, Michael G. Rock, Daniel J. Berry, Bernard F. Morrey, Mark E. Bolander

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The unique design characteristics of an uncemented femoral component were used to study differences in the periprosthetic membranes in the presence and absence of osteolysis. A component (Omniflex, Osteonics, Allendale, NJ) that has a large midportion of the stem that does not contact bone was studied. A membrane forms, even in the absence of bone resorption, in Gruen zones 3 and 5 of this component. Analysis of this membrane showed noninflammatory fibrous tissue, no or minimal particulate debris, and few macrophages. In contrast, analysis of membranes from osteolytic regions around the same prosthesis demonstrated typical inflammatory characteristics. Collagenase, gelatinase, and stromelysin expression was high in osteolytic membranes but was low in tissues from noninflammatory regions without osteolysis. The data suggest a sequence of events in periprosthetic membrane formation. A noninflammatory membrane initially forms between the bone and the prosthesis. This membrane is transformed into an inflammatory membrane by the influx of particulate debris. Matrix metalloproteinases are selectively expressed in regions of osteolysis, implicating these enzymes in periprosthetic bone loss and suggesting a possible level for pharmaceutical intervention to prevent or treat osteolysis. Formation of the noninflammatory membrane around the distal part of the prosthesis of this or similar designs in the absence of bone resorption implies that these tissue samples could serve as useful negative control tissues to identify factors present in osteolytic periprosthetic membranes.

Original languageEnglish (US)
Pages (from-to)320-330
Number of pages11
JournalJournal of Arthroplasty
Volume13
Issue number3
DOIs
StatePublished - Apr 1998
Externally publishedYes

Fingerprint

Thigh
Arthroplasty
Hip
Membranes
Osteolysis
Prostheses and Implants
Bone Resorption
Bone and Bones
Matrix Metalloproteinase 3
Gelatinases
Collagenases
Matrix Metalloproteinases
Macrophages

Keywords

  • Arthroplasty
  • Biochemistry
  • Histology
  • Matrix metalloproteinase
  • Osteolysis
  • Total hip prosthesis

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

Histologic and biochemical differences between osteolytic and nonosteolytic membranes around femoral components of an uncemented total hip arthroplasty. / Vidovszky, Tamas J; Cabanela, Miguel E.; Rock, Michael G.; Berry, Daniel J.; Morrey, Bernard F.; Bolander, Mark E.

In: Journal of Arthroplasty, Vol. 13, No. 3, 04.1998, p. 320-330.

Research output: Contribution to journalArticle

Vidovszky, Tamas J ; Cabanela, Miguel E. ; Rock, Michael G. ; Berry, Daniel J. ; Morrey, Bernard F. ; Bolander, Mark E. / Histologic and biochemical differences between osteolytic and nonosteolytic membranes around femoral components of an uncemented total hip arthroplasty. In: Journal of Arthroplasty. 1998 ; Vol. 13, No. 3. pp. 320-330.
@article{5d1eafbd4cef49e496db13b50bd3aac0,
title = "Histologic and biochemical differences between osteolytic and nonosteolytic membranes around femoral components of an uncemented total hip arthroplasty",
abstract = "The unique design characteristics of an uncemented femoral component were used to study differences in the periprosthetic membranes in the presence and absence of osteolysis. A component (Omniflex, Osteonics, Allendale, NJ) that has a large midportion of the stem that does not contact bone was studied. A membrane forms, even in the absence of bone resorption, in Gruen zones 3 and 5 of this component. Analysis of this membrane showed noninflammatory fibrous tissue, no or minimal particulate debris, and few macrophages. In contrast, analysis of membranes from osteolytic regions around the same prosthesis demonstrated typical inflammatory characteristics. Collagenase, gelatinase, and stromelysin expression was high in osteolytic membranes but was low in tissues from noninflammatory regions without osteolysis. The data suggest a sequence of events in periprosthetic membrane formation. A noninflammatory membrane initially forms between the bone and the prosthesis. This membrane is transformed into an inflammatory membrane by the influx of particulate debris. Matrix metalloproteinases are selectively expressed in regions of osteolysis, implicating these enzymes in periprosthetic bone loss and suggesting a possible level for pharmaceutical intervention to prevent or treat osteolysis. Formation of the noninflammatory membrane around the distal part of the prosthesis of this or similar designs in the absence of bone resorption implies that these tissue samples could serve as useful negative control tissues to identify factors present in osteolytic periprosthetic membranes.",
keywords = "Arthroplasty, Biochemistry, Histology, Matrix metalloproteinase, Osteolysis, Total hip prosthesis",
author = "Vidovszky, {Tamas J} and Cabanela, {Miguel E.} and Rock, {Michael G.} and Berry, {Daniel J.} and Morrey, {Bernard F.} and Bolander, {Mark E.}",
year = "1998",
month = "4",
doi = "10.1016/S0883-5403(98)90178-4",
language = "English (US)",
volume = "13",
pages = "320--330",
journal = "Journal of Arthroplasty",
issn = "0883-5403",
publisher = "Churchill Livingstone",
number = "3",

}

TY - JOUR

T1 - Histologic and biochemical differences between osteolytic and nonosteolytic membranes around femoral components of an uncemented total hip arthroplasty

AU - Vidovszky, Tamas J

AU - Cabanela, Miguel E.

AU - Rock, Michael G.

AU - Berry, Daniel J.

AU - Morrey, Bernard F.

AU - Bolander, Mark E.

PY - 1998/4

Y1 - 1998/4

N2 - The unique design characteristics of an uncemented femoral component were used to study differences in the periprosthetic membranes in the presence and absence of osteolysis. A component (Omniflex, Osteonics, Allendale, NJ) that has a large midportion of the stem that does not contact bone was studied. A membrane forms, even in the absence of bone resorption, in Gruen zones 3 and 5 of this component. Analysis of this membrane showed noninflammatory fibrous tissue, no or minimal particulate debris, and few macrophages. In contrast, analysis of membranes from osteolytic regions around the same prosthesis demonstrated typical inflammatory characteristics. Collagenase, gelatinase, and stromelysin expression was high in osteolytic membranes but was low in tissues from noninflammatory regions without osteolysis. The data suggest a sequence of events in periprosthetic membrane formation. A noninflammatory membrane initially forms between the bone and the prosthesis. This membrane is transformed into an inflammatory membrane by the influx of particulate debris. Matrix metalloproteinases are selectively expressed in regions of osteolysis, implicating these enzymes in periprosthetic bone loss and suggesting a possible level for pharmaceutical intervention to prevent or treat osteolysis. Formation of the noninflammatory membrane around the distal part of the prosthesis of this or similar designs in the absence of bone resorption implies that these tissue samples could serve as useful negative control tissues to identify factors present in osteolytic periprosthetic membranes.

AB - The unique design characteristics of an uncemented femoral component were used to study differences in the periprosthetic membranes in the presence and absence of osteolysis. A component (Omniflex, Osteonics, Allendale, NJ) that has a large midportion of the stem that does not contact bone was studied. A membrane forms, even in the absence of bone resorption, in Gruen zones 3 and 5 of this component. Analysis of this membrane showed noninflammatory fibrous tissue, no or minimal particulate debris, and few macrophages. In contrast, analysis of membranes from osteolytic regions around the same prosthesis demonstrated typical inflammatory characteristics. Collagenase, gelatinase, and stromelysin expression was high in osteolytic membranes but was low in tissues from noninflammatory regions without osteolysis. The data suggest a sequence of events in periprosthetic membrane formation. A noninflammatory membrane initially forms between the bone and the prosthesis. This membrane is transformed into an inflammatory membrane by the influx of particulate debris. Matrix metalloproteinases are selectively expressed in regions of osteolysis, implicating these enzymes in periprosthetic bone loss and suggesting a possible level for pharmaceutical intervention to prevent or treat osteolysis. Formation of the noninflammatory membrane around the distal part of the prosthesis of this or similar designs in the absence of bone resorption implies that these tissue samples could serve as useful negative control tissues to identify factors present in osteolytic periprosthetic membranes.

KW - Arthroplasty

KW - Biochemistry

KW - Histology

KW - Matrix metalloproteinase

KW - Osteolysis

KW - Total hip prosthesis

UR - http://www.scopus.com/inward/record.url?scp=0031948371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031948371&partnerID=8YFLogxK

U2 - 10.1016/S0883-5403(98)90178-4

DO - 10.1016/S0883-5403(98)90178-4

M3 - Article

C2 - 9590644

AN - SCOPUS:0031948371

VL - 13

SP - 320

EP - 330

JO - Journal of Arthroplasty

JF - Journal of Arthroplasty

SN - 0883-5403

IS - 3

ER -