Histiocytic typhlocolitis in two colony Beagle dogs

Francisco R Carvallo chaigneau, Roy Kerlin, Claudine Fredette, Harshan Pisharath, Chitrita DebRoy, Subhashinie Kariyawasam, Ingrid D. Pardo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Two young female Beagle dogs in a laboratory colony with clinical signs of loose stools and fecal blood were confirmed to have histiocytic ulcerative colitis by histologic evaluation. This syndrome is well recognized in other dog breeds such as Boxers and related French Bulldogs, Mastiffs, Alaskan malamutes and Doberman Pinschers. Formalin-fixed paraffin sections of large intestine from one dog demonstrated the presence of Escherichia coli strain LF82 by immunohistochemistry and 16S ribosomal RNA gene sequencing. E coli strain LF82 has been implicated in the pathogenesis of Crohn's disease and similar bacteria have been cultured from cases of histiocytic ulcerative colitis in Boxer dogs. Spontaneous histiocytic ulcerative colitis must be differentiated from test article-related findings in nonclinical toxicity studies in Beagle dogs.

Original languageEnglish (US)
Pages (from-to)219-221
Number of pages3
JournalExperimental and Toxicologic Pathology
Volume67
Issue number2
DOIs
StatePublished - Feb 1 2015

Fingerprint

Escherichia coli
Dogs
16S Ribosomal RNA
Ulcerative Colitis
Paraffin
Formaldehyde
Toxicity
Bacteria
Blood
Genes
RNA Sequence Analysis
Large Intestine
rRNA Genes
Crohn Disease
Immunohistochemistry

Keywords

  • Crohn's disease
  • Escherichia coli strain LF82
  • Granulomatous colitis
  • Ulcerative colitis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Cell Biology

Cite this

Carvallo chaigneau, F. R., Kerlin, R., Fredette, C., Pisharath, H., DebRoy, C., Kariyawasam, S., & Pardo, I. D. (2015). Histiocytic typhlocolitis in two colony Beagle dogs. Experimental and Toxicologic Pathology, 67(2), 219-221. https://doi.org/10.1016/j.etp.2014.10.004

Histiocytic typhlocolitis in two colony Beagle dogs. / Carvallo chaigneau, Francisco R; Kerlin, Roy; Fredette, Claudine; Pisharath, Harshan; DebRoy, Chitrita; Kariyawasam, Subhashinie; Pardo, Ingrid D.

In: Experimental and Toxicologic Pathology, Vol. 67, No. 2, 01.02.2015, p. 219-221.

Research output: Contribution to journalArticle

Carvallo chaigneau, FR, Kerlin, R, Fredette, C, Pisharath, H, DebRoy, C, Kariyawasam, S & Pardo, ID 2015, 'Histiocytic typhlocolitis in two colony Beagle dogs', Experimental and Toxicologic Pathology, vol. 67, no. 2, pp. 219-221. https://doi.org/10.1016/j.etp.2014.10.004
Carvallo chaigneau, Francisco R ; Kerlin, Roy ; Fredette, Claudine ; Pisharath, Harshan ; DebRoy, Chitrita ; Kariyawasam, Subhashinie ; Pardo, Ingrid D. / Histiocytic typhlocolitis in two colony Beagle dogs. In: Experimental and Toxicologic Pathology. 2015 ; Vol. 67, No. 2. pp. 219-221.
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