Hippocampal volume and retention in Alzheimer's disease

Joel H. Kramer, Norbert Schuff, Bruce R Reed, Dan M Mungas, An Tao Du, Howard J. Rosen, William J. Jagust, Bruce L. Miller, Michael W. Weiner, Helena C. Chui

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


This study tested the hypothesis that the hippocampus has a relatively specific role in retaining information over delays. Thirty-seven subjects with probable Alzheimer's disease were evaluated with a verbal memory task and structural MRI. Cortical gray matter but not hippocampal volume predicted immediate free recall. In contrast, hippocampal volume was the best predictor of how well information was retained over a delay, even after controlling for levels of immediate recall. Results suggest that the role of the hippocampus is relatively specific to the consolidation of new memories.

Original languageEnglish (US)
Pages (from-to)639-643
Number of pages5
JournalJournal of the International Neuropsychological Society
Issue number4
StatePublished - Jul 2004


  • Alzheimer's disease
  • Consolidation
  • Hippocampus
  • Memory

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)


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