Hippocampal volume and glucose metabolism in temporal lobe epileptic foci

William H. Theodore, William D. Gaillard, Charles DeCarli, Sanjiv Bhatia, Junko Hatta

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Purpose: Reports conflict on the relation of glucose metabolism to hippocampal volume in temporal lobe foci. Previous studies usually have used side-side ratios rather than regional metabolic rates. Methods: We measured hippocampal volume and glucose metabolism in 37 patients with temporal epileptogenic zones identified by ictal video-EEG telemetry. Metabolic rates were normalized to global brain mean. Results: Both 18-fluoro-2-deoxyglucose-PET and volumetric MRI lateralized the epileptic focus determined by ictal video-EEG. There were significant correlations between leftright metabolic asymmetry and hippocampal formation volume left-right ratios. Comparisons between normalized metabolism and hippocampal formation volume, ignoring the side of the epileptic focus, showed significant relations between left hippocampal volume and left inferior lateral temporal metabolism, right hippocampus and right inferior mesial temporal, and left hippocampus and left inferior mesial temporal metabolism. In contrast, when normalized metabolism was compared with hippocampal volume in the epileptic focus, no relation was found. Conclusions: Our study suggests that the relation between hippocampal volume and glucose metabolism breaks down in epileptic foci and that hypometabolism is not dependent on neuronal loss. It is consistent with data suggesting that hypometabolism is an independent predictor of surgical outcome.

Original languageEnglish (US)
Pages (from-to)130-132
Number of pages3
JournalEpilepsia
Volume42
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Epilepsy
  • Glucose metabolism
  • Ippocampus
  • MRI
  • PET

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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