Hippocampal theta dysfunction after lateral fluid percussion injury

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Chronic memory deficits are a major cause of morbidity following traumatic brain injury (TBI). In the rat, the hippocampal theta rhythm is a well-studied correlate of memory function. This study sought to investigate disturbances in hippocampal theta rhythm following lateral fluid percussion injury in the rat. A total of 13 control rats and 12 TBI rats were used. Electrodes were implanted in bilateral hippocampi and an electroencephalogram (EEG) was recorded while the rats explored a new environment, and also while navigating a modified version of the Barnes maze. Theta power and peak theta frequency were significantly attenuated in the injured animals. Further, injured rats were less likely to develop a spatial strategy for Barnes maze navigation compared to control rats. In conclusion, rats sustaining lateral fluid percussion injury demonstrated deficits in hippocampal theta activity. These deficits may contribute to the underlying memory problems seen in chronic TBI.

Original languageEnglish (US)
Pages (from-to)1605-1615
Number of pages11
JournalJournal of Neurotrauma
Volume27
Issue number9
DOIs
StatePublished - Sep 1 2010

Fingerprint

Percussion
Wounds and Injuries
Theta Rhythm
Chronic Brain Injury
Implanted Electrodes
Memory Disorders
Electroencephalography
Hippocampus
Morbidity

Keywords

  • electroencephalogram
  • fluid percussion injury
  • memory
  • rat
  • theta rhythm
  • traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Hippocampal theta dysfunction after lateral fluid percussion injury. / Fedor, Mark; Berman, Robert F; Muizelaar, Jan Paul; Lyeth, Bruce G.

In: Journal of Neurotrauma, Vol. 27, No. 9, 01.09.2010, p. 1605-1615.

Research output: Contribution to journalArticle

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