Hippocampal sclerosis is a progressive disorder: A longitudinal volumetric MRI study

Darren Fuerst, Jagdish Shah, Aashit Shah, Craig Watson

Research output: Contribution to journalArticle

164 Scopus citations

Abstract

Twelve patients with refractory temporal lobe epilepsy and unilateral hippocampal sclerosis had repeat volumetric magnetic resonance imaging scans after a mean of 3.4 years to determine whether progressive hippocampal volume loss occurred. Seizure-free patients showed no change in hippocampal volume. Patients with continuing seizures had a decline in ipsilateral hippocampal volume that correlated with seizure frequency. Patients with medically refractory temporal lobe epilepsy and unilateral hippocampal sclerosis have progressive hippocampal atrophy.

Original languageEnglish (US)
Pages (from-to)413-416
Number of pages4
JournalAnnals of Neurology
Volume53
Issue number3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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