Hippocampal sclerosis and the syndrome of medial temporal lobe epilepsy

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2 Scopus citations


Medial temporal lobe epilepsy due to hippocampal sclerosis is the most common epileptic syndrome and, if medically refractory, is a progressive disorder. Advances over the past decade allow this clinicopathological syndrome to be diagnosed in vivo. Many patients with hippocampal sclerosis become refractory to antiepileptic medications and are at risk of progressive hippocampal damage, cognitive deterioration and other disabling manifestations of refractory epilepsy. Fortunately, if hippocampal sclerosis is detected early and treated surgically, most patients with this syndrome can be rendered seizure-free, thus sparing them from further progression and disability.

Original languageEnglish (US)
Pages (from-to)821-828
Number of pages8
JournalExpert Review of Neurotherapeutics
Issue number6
StatePublished - Nov 2003
Externally publishedYes


  • Anterior temporal lobectomy
  • Hippocampal sclerosis
  • Medial temporal lobe epilepsy
  • PET scanning
  • Volumetric MRI

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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