Hippocampal neurophysiologic changes after mild traumatic brain injury and potential neuromodulation treatment approaches

Fady Girgis, Jonathan Pace, Jennifer Sweet, Jonathan P. Miller

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

Traumatic brain injury (TBI) is the leading cause of death and disability in individuals below age 45, and five million Americans live with chronic disability as a result. Mild TBI (mTBI), defined as TBI in the absence of major imaging or histopathological defects, is responsible for a majority of cases. Despite the lack of overt morphological defects, victims of mTBI frequently suffer lasting cognitive deficits, memory difficulties, and behavioral disturbances. There is increasing evidence that cognitive and memory dysfunction is related to subtle physiological changes that occur in the hippocampus, and these impact both the phenotype of deficits observed and subsequent recovery. Therapeutic modulation of physiological activity by means of medications commonly used for other indications or brain stimulation may represent novel treatment approaches. This review summarizes the present body of knowledge regarding neurophysiologic changes that occur in the hippocampus after mTBI, as well as potential targets for therapeutic modulation of neurologic activity.

Original languageEnglish (US)
Article number8
JournalFrontiers in Systems Neuroscience
Volume10
Issue numberFEB
DOIs
StatePublished - Feb 9 2016
Externally publishedYes

Keywords

  • Cognitive dysfunction
  • Drug repositioning
  • Hippocampus
  • Mild traumatic brain injury
  • Neuromodulation
  • Neurophysiology

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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