Hippocampal dysplasia in rats exposed to cocaine in utero

Scott C. Baraban, H. Jurgen Wenzel, Peter A. Castro, Philip A Schwartzkroin

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Prenatal cocaine exposure can result in neurobehavioral disturbances and structural modifications of the central nervous system. In the present study, cocaine was injected into pregnant rats and the brains of their offspring were examined at the light microscopic level. As adults, cocaine-exposed offspring exhibited subtle, but consistent, hippocampal abnormalities. In particular, the stratum pyramidale (particularly the CA1 region) was interrupted by frequent gaps in lamination, and ectopic pyramidal cells were found in stratum oriens and radiatum. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)213-217
Number of pages5
JournalDevelopmental Brain Research
Issue number2
StatePublished - Nov 18 1999
Externally publishedYes


  • Brain
  • Drug abuse
  • Ectopic
  • Migration
  • Prenatal

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience


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