Abstract
Prenatal cocaine exposure can result in neurobehavioral disturbances and structural modifications of the central nervous system. In the present study, cocaine was injected into pregnant rats and the brains of their offspring were examined at the light microscopic level. As adults, cocaine-exposed offspring exhibited subtle, but consistent, hippocampal abnormalities. In particular, the stratum pyramidale (particularly the CA1 region) was interrupted by frequent gaps in lamination, and ectopic pyramidal cells were found in stratum oriens and radiatum. Copyright (C) 1999 Elsevier Science B.V.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 213-217 |
| Number of pages | 5 |
| Journal | Developmental Brain Research |
| Volume | 117 |
| Issue number | 2 |
| DOIs | |
| State | Published - Nov 18 1999 |
| Externally published | Yes |
Keywords
- Brain
- Drug abuse
- Ectopic
- Migration
- Prenatal
ASJC Scopus subject areas
- Developmental Biology
- Developmental Neuroscience
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Cite this
Baraban, S. C., Wenzel, H. J., Castro, P. A., & Schwartzkroin, P. A. (1999). Hippocampal dysplasia in rats exposed to cocaine in utero. Developmental Brain Research, 117(2), 213-217. https://doi.org/10.1016/S0165-3806(99)00106-6