Hippocampal atrophy in early Alzheimer's Disease: Anatomic specificity and validation

A. Convit, M. J. de Leon, J. Golomb, A. E. George, C. Y. Tarshish, Matthew Bobinski, W. Tsui, S. De Santi, J. Wegiel, H. Wisniewski

Research output: Contribution to journalArticlepeer-review

114 Scopus citations


We evaluated three groups of elderly individuals who were carefully screened to rule out clinically significant diseases that could affect cognition. They were matched for age and education. The groups included normals (N=18), Alzheimer's Disease (AD) patients (N=15), and minimally impaired individuals with memory complaints and impairments but who did not fulfill criteria for AD (N=17). Volumetric measurements of different regions of the temporal lobe on the coronal scan as well as ratings of the perihippocampal cerebrospinal fluid (CSF) accumulation (HCSF) on the negative angle axial MR were carried out. Volume reductions were found in AD relative to the normals for both medial and lateral temporal lobe volumes. Only hippocampal volume reductions were found in the minimal group. The minimally impaired individuals had equivalent hippocampal volume reductions and significantly larger parahippocampal and lateral temporal lobe gyri than the AD group. The axial HCSF was validated using the coronal volumes. The combination of coronal hippocampal and perihippocampal CSF was the best predictor of the axial HCSF rating. The parahippocampal volume did not add to the predictive ability of the hippocampal-perihippocampal CSF combination. Future work should validate these findings with longitudinal designs as well as assess the issue of normal aging of these structures and their relationship to cognitive function.

Original languageEnglish (US)
Pages (from-to)371-387
Number of pages17
JournalPsychiatric Quarterly
Issue number4
StatePublished - Dec 1993
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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