Hippocampal atrophy, epilepsy duration, and febrile seizures in patients with partial seizures

William H. Theodore, S. Bhatia, J. Hatta, S. Fazilat, Charles DeCarli, S. Y. Bookheimer, W. D. Gaillard

Research output: Contribution to journalArticle

183 Citations (Scopus)

Abstract

Background: Previous studies have suggested a variety of factors that may be associated with the presence of hippocampal formation (HF) atrophy in patients with complex partial seizures (CPS), including a history of complex or prolonged febrile seizures (FS), age at seizure onset, and epilepsy duration. Objective: To determine whether epilepsy duration is related to HF atrophy. Methods: We performed MRIs on 35 patients with uncontrolled CPS who had temporal lobe ictal onset on video-EEG. None had evidence for an alien tissue lesion or extra-hippocampal seizure onset. All had a history of secondary generalization. Brain structures were drawn on consecutive images and pixel points summed from successive pictures to calculate volumes. Results: Nine patients with a history of complex or prolonged FS had smaller ipsilateral HF volume and ipsilateral/contralateral ratio than did patients without a history of FS. Epilepsy duration had a significant relation to ipsilateral HF volume and ipsilateral/contralateral ratio. In a multivariate analysis, the effect of duration, but not age at onset or scan, was significant. Patients with a history of FS did not have earlier age at epilepsy onset or longer duration. Conclusions: A history of FS predicted the severity of HF atrophy in our patients. Age at onset or study was not a significant factor. Epilepsy duration, however, did have a significant effect, suggesting that, after an initial insult, progressive HF damage may occur in patients with persistent seizures.

Original languageEnglish (US)
Pages (from-to)132-136
Number of pages5
JournalNeurology
Volume52
Issue number1
StatePublished - Jan 1 1999
Externally publishedYes

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Febrile Seizures
Atrophy
Epilepsy
Seizures
Hippocampus
Age of Onset
Temporal Lobe
Electroencephalography
Multivariate Analysis
Stroke
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Theodore, W. H., Bhatia, S., Hatta, J., Fazilat, S., DeCarli, C., Bookheimer, S. Y., & Gaillard, W. D. (1999). Hippocampal atrophy, epilepsy duration, and febrile seizures in patients with partial seizures. Neurology, 52(1), 132-136.

Hippocampal atrophy, epilepsy duration, and febrile seizures in patients with partial seizures. / Theodore, William H.; Bhatia, S.; Hatta, J.; Fazilat, S.; DeCarli, Charles; Bookheimer, S. Y.; Gaillard, W. D.

In: Neurology, Vol. 52, No. 1, 01.01.1999, p. 132-136.

Research output: Contribution to journalArticle

Theodore, WH, Bhatia, S, Hatta, J, Fazilat, S, DeCarli, C, Bookheimer, SY & Gaillard, WD 1999, 'Hippocampal atrophy, epilepsy duration, and febrile seizures in patients with partial seizures', Neurology, vol. 52, no. 1, pp. 132-136.
Theodore WH, Bhatia S, Hatta J, Fazilat S, DeCarli C, Bookheimer SY et al. Hippocampal atrophy, epilepsy duration, and febrile seizures in patients with partial seizures. Neurology. 1999 Jan 1;52(1):132-136.
Theodore, William H. ; Bhatia, S. ; Hatta, J. ; Fazilat, S. ; DeCarli, Charles ; Bookheimer, S. Y. ; Gaillard, W. D. / Hippocampal atrophy, epilepsy duration, and febrile seizures in patients with partial seizures. In: Neurology. 1999 ; Vol. 52, No. 1. pp. 132-136.
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