Hippocampal Activity Patterns Carry Information about Objects in Temporal Context

Liang Tien Hsieh, Matthias J. Gruber, Lucas J. Jenkins, Charan Ranganath

Research output: Contribution to journalArticle

166 Scopus citations

Abstract

The hippocampus is critical for human episodic memory, but its role remains controversial. One fundamental question concerns whether the hippocampus represents specific objects or assigns context-dependent representations to objects. Here, we used multivoxel pattern similarity analysis of fMRI data during retrieval of learned object sequences to systematically investigate hippocampal coding of object and temporal context information. Hippocampal activity patterns carried information about the temporal positions of objects in learned sequences, but not about objects or temporal positions in random sequences. Hippocampal activity patterns differentiated between overlapping object sequences and between temporally adjacent objects that belonged to distinct sequence contexts. Parahippocampal and perirhinal cortex showed different pattern information profiles consistent with coding of temporal position and object information, respectively. These findings are consistent with models proposing that the hippocampus represents objects within specific temporal contexts, a capability that might explain its critical role in episodic memory.

Original languageEnglish (US)
Pages (from-to)1165-1178
Number of pages14
JournalNeuron
Volume81
Issue number5
DOIs
StatePublished - Mar 5 2014

ASJC Scopus subject areas

  • Neuroscience(all)

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    Hsieh, L. T., Gruber, M. J., Jenkins, L. J., & Ranganath, C. (2014). Hippocampal Activity Patterns Carry Information about Objects in Temporal Context. Neuron, 81(5), 1165-1178. https://doi.org/10.1016/j.neuron.2014.01.015