Hindbrain herniation develops in surgically created myelomeningocele but is absent after repair in fetal lambs

Bettina W. Paek, Diana L Farmer, C. Corbett Wilkinson, Craig T. Albanese, Warrick Peacock, Michael R. Harrison, Russell W. Jennings

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

OBJECTIVE: The purpose of our study was to determine whether prenatal repair of myelomeningocele prevents or reverses hindbrain herniation in the sheep model. STUDY DESIGN: A myelomeningocele was surgically created in fetal sheep. One group was repaired later in utero; the others were delivered without repair. After delivery, lambs were assessed for the presence of hindbrain herniation. RESULTS: In all lambs that had not undergone repair of the myelomeningocele, severe hindbrain herniation developed, whereas the brains of all lambs that had undergone fetal repair were normal. CONCLUSION: Prenatal repair of myelomeningocele prevents or reverses development of hindbrain herniation in the fetal lamb model.

Original languageEnglish (US)
Pages (from-to)1119-1123
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume183
Issue number5
DOIs
StatePublished - 2000

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Meningomyelocele
Rhombencephalon
Sheep
Brain

Keywords

  • Fetal surgery
  • Hindbrain herniation
  • Myelomeningocele
  • Sheep

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Hindbrain herniation develops in surgically created myelomeningocele but is absent after repair in fetal lambs. / Paek, Bettina W.; Farmer, Diana L; Wilkinson, C. Corbett; Albanese, Craig T.; Peacock, Warrick; Harrison, Michael R.; Jennings, Russell W.

In: American Journal of Obstetrics and Gynecology, Vol. 183, No. 5, 2000, p. 1119-1123.

Research output: Contribution to journalArticle

Paek, Bettina W. ; Farmer, Diana L ; Wilkinson, C. Corbett ; Albanese, Craig T. ; Peacock, Warrick ; Harrison, Michael R. ; Jennings, Russell W. / Hindbrain herniation develops in surgically created myelomeningocele but is absent after repair in fetal lambs. In: American Journal of Obstetrics and Gynecology. 2000 ; Vol. 183, No. 5. pp. 1119-1123.
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AU - Peacock, Warrick

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