Hindbrain herniation develops in surgically created myelomeningocele but is absent after repair in fetal lambs

Bettina W. Paek, Diana L Farmer, C. Corbett Wilkinson, Craig T. Albanese, Warrick Peacock, Michael R. Harrison, Russell W. Jennings

Research output: Contribution to journalArticle

113 Scopus citations

Abstract

OBJECTIVE: The purpose of our study was to determine whether prenatal repair of myelomeningocele prevents or reverses hindbrain herniation in the sheep model. STUDY DESIGN: A myelomeningocele was surgically created in fetal sheep. One group was repaired later in utero; the others were delivered without repair. After delivery, lambs were assessed for the presence of hindbrain herniation. RESULTS: In all lambs that had not undergone repair of the myelomeningocele, severe hindbrain herniation developed, whereas the brains of all lambs that had undergone fetal repair were normal. CONCLUSION: Prenatal repair of myelomeningocele prevents or reverses development of hindbrain herniation in the fetal lamb model.

Original languageEnglish (US)
Pages (from-to)1119-1123
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume183
Issue number5
DOIs
StatePublished - 2000

Keywords

  • Fetal surgery
  • Hindbrain herniation
  • Myelomeningocele
  • Sheep

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

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