Highly polymorphic repeat marker within the β-amyloid precursor protein gene

Stefania Zappata, Michael B. Petersen, Ulrich König, Jillian Blaschak, Arvinda Chakravarti, Flora Tassone, Angelo Serra, Stylianos E. Antonarakis, Christina Brahe

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We have identified a polymorphic compound dinucleotide repeat sequence in intron 1 of the β-amyloid precursor protein (APP) gene on chromosome 21. Using polymerase chain reaction (PCR) amplification of the locus, designated APPivsl, we detected 13 alleles in the CEPH family members (heterozygosity = 0.69). Lod score analysis showed complete linkage of the marker to the loci D21S210 and D21221.

Original languageEnglish (US)
Pages (from-to)85-86
Number of pages2
JournalHuman Genetics
Volume93
Issue number1
DOIs
StatePublished - Jan 1994
Externally publishedYes

Fingerprint

Dinucleotide Repeats
Lod Score
Chromosomes, Human, Pair 21
Amyloid beta-Protein Precursor
Introns
Alleles
Polymerase Chain Reaction
Genes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Zappata, S., Petersen, M. B., König, U., Blaschak, J., Chakravarti, A., Tassone, F., ... Brahe, C. (1994). Highly polymorphic repeat marker within the β-amyloid precursor protein gene. Human Genetics, 93(1), 85-86. https://doi.org/10.1007/BF00218922

Highly polymorphic repeat marker within the β-amyloid precursor protein gene. / Zappata, Stefania; Petersen, Michael B.; König, Ulrich; Blaschak, Jillian; Chakravarti, Arvinda; Tassone, Flora; Serra, Angelo; Antonarakis, Stylianos E.; Brahe, Christina.

In: Human Genetics, Vol. 93, No. 1, 01.1994, p. 85-86.

Research output: Contribution to journalArticle

Zappata, S, Petersen, MB, König, U, Blaschak, J, Chakravarti, A, Tassone, F, Serra, A, Antonarakis, SE & Brahe, C 1994, 'Highly polymorphic repeat marker within the β-amyloid precursor protein gene', Human Genetics, vol. 93, no. 1, pp. 85-86. https://doi.org/10.1007/BF00218922
Zappata S, Petersen MB, König U, Blaschak J, Chakravarti A, Tassone F et al. Highly polymorphic repeat marker within the β-amyloid precursor protein gene. Human Genetics. 1994 Jan;93(1):85-86. https://doi.org/10.1007/BF00218922
Zappata, Stefania ; Petersen, Michael B. ; König, Ulrich ; Blaschak, Jillian ; Chakravarti, Arvinda ; Tassone, Flora ; Serra, Angelo ; Antonarakis, Stylianos E. ; Brahe, Christina. / Highly polymorphic repeat marker within the β-amyloid precursor protein gene. In: Human Genetics. 1994 ; Vol. 93, No. 1. pp. 85-86.
@article{6d38ccc2a18140349e70ad07618e7053,
title = "Highly polymorphic repeat marker within the β-amyloid precursor protein gene",
abstract = "We have identified a polymorphic compound dinucleotide repeat sequence in intron 1 of the β-amyloid precursor protein (APP) gene on chromosome 21. Using polymerase chain reaction (PCR) amplification of the locus, designated APPivsl, we detected 13 alleles in the CEPH family members (heterozygosity = 0.69). Lod score analysis showed complete linkage of the marker to the loci D21S210 and D21221.",
author = "Stefania Zappata and Petersen, {Michael B.} and Ulrich K{\"o}nig and Jillian Blaschak and Arvinda Chakravarti and Flora Tassone and Angelo Serra and Antonarakis, {Stylianos E.} and Christina Brahe",
year = "1994",
month = "1",
doi = "10.1007/BF00218922",
language = "English (US)",
volume = "93",
pages = "85--86",
journal = "Human Genetics",
issn = "0340-6717",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Highly polymorphic repeat marker within the β-amyloid precursor protein gene

AU - Zappata, Stefania

AU - Petersen, Michael B.

AU - König, Ulrich

AU - Blaschak, Jillian

AU - Chakravarti, Arvinda

AU - Tassone, Flora

AU - Serra, Angelo

AU - Antonarakis, Stylianos E.

AU - Brahe, Christina

PY - 1994/1

Y1 - 1994/1

N2 - We have identified a polymorphic compound dinucleotide repeat sequence in intron 1 of the β-amyloid precursor protein (APP) gene on chromosome 21. Using polymerase chain reaction (PCR) amplification of the locus, designated APPivsl, we detected 13 alleles in the CEPH family members (heterozygosity = 0.69). Lod score analysis showed complete linkage of the marker to the loci D21S210 and D21221.

AB - We have identified a polymorphic compound dinucleotide repeat sequence in intron 1 of the β-amyloid precursor protein (APP) gene on chromosome 21. Using polymerase chain reaction (PCR) amplification of the locus, designated APPivsl, we detected 13 alleles in the CEPH family members (heterozygosity = 0.69). Lod score analysis showed complete linkage of the marker to the loci D21S210 and D21221.

UR - http://www.scopus.com/inward/record.url?scp=0027955492&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027955492&partnerID=8YFLogxK

U2 - 10.1007/BF00218922

DO - 10.1007/BF00218922

M3 - Article

C2 - 8270262

AN - SCOPUS:0027955492

VL - 93

SP - 85

EP - 86

JO - Human Genetics

JF - Human Genetics

SN - 0340-6717

IS - 1

ER -