Highly polymorphic repeat marker within the β-amyloid precursor protein gene

Stefania Zappata, Michael B. Petersen, Ulrich König, Jillian Blaschak, Arvinda Chakravarti, Flora Tassone, Angelo Serra, Stylianos E. Antonarakis, Christina Brahe

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

We have identified a polymorphic compound dinucleotide repeat sequence in intron 1 of the β-amyloid precursor protein (APP) gene on chromosome 21. Using polymerase chain reaction (PCR) amplification of the locus, designated APPivsl, we detected 13 alleles in the CEPH family members (heterozygosity = 0.69). Lod score analysis showed complete linkage of the marker to the loci D21S210 and D21221.

Original languageEnglish (US)
Pages (from-to)85-86
Number of pages2
JournalHuman Genetics
Volume93
Issue number1
DOIs
StatePublished - Jan 1994
Externally publishedYes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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