Abstract
We have identified a polymorphic compound dinucleotide repeat sequence in intron 1 of the β-amyloid precursor protein (APP) gene on chromosome 21. Using polymerase chain reaction (PCR) amplification of the locus, designated APPivsl, we detected 13 alleles in the CEPH family members (heterozygosity = 0.69). Lod score analysis showed complete linkage of the marker to the loci D21S210 and D21221.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 85-86 |
| Number of pages | 2 |
| Journal | Human Genetics |
| Volume | 93 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1994 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Genetics(clinical)
- Genetics
Cite this
Highly polymorphic repeat marker within the β-amyloid precursor protein gene. / Zappata, Stefania; Petersen, Michael B.; König, Ulrich; Blaschak, Jillian; Chakravarti, Arvinda; Tassone, Flora; Serra, Angelo; Antonarakis, Stylianos E.; Brahe, Christina.
In: Human Genetics, Vol. 93, No. 1, 01.1994, p. 85-86.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Highly polymorphic repeat marker within the β-amyloid precursor protein gene
AU - Zappata, Stefania
AU - Petersen, Michael B.
AU - König, Ulrich
AU - Blaschak, Jillian
AU - Chakravarti, Arvinda
AU - Tassone, Flora
AU - Serra, Angelo
AU - Antonarakis, Stylianos E.
AU - Brahe, Christina
PY - 1994/1
Y1 - 1994/1
N2 - We have identified a polymorphic compound dinucleotide repeat sequence in intron 1 of the β-amyloid precursor protein (APP) gene on chromosome 21. Using polymerase chain reaction (PCR) amplification of the locus, designated APPivsl, we detected 13 alleles in the CEPH family members (heterozygosity = 0.69). Lod score analysis showed complete linkage of the marker to the loci D21S210 and D21221.
AB - We have identified a polymorphic compound dinucleotide repeat sequence in intron 1 of the β-amyloid precursor protein (APP) gene on chromosome 21. Using polymerase chain reaction (PCR) amplification of the locus, designated APPivsl, we detected 13 alleles in the CEPH family members (heterozygosity = 0.69). Lod score analysis showed complete linkage of the marker to the loci D21S210 and D21221.
UR - http://www.scopus.com/inward/record.url?scp=0027955492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027955492&partnerID=8YFLogxK
U2 - 10.1007/BF00218922
DO - 10.1007/BF00218922
M3 - Article
C2 - 8270262
AN - SCOPUS:0027955492
VL - 93
SP - 85
EP - 86
JO - Human Genetics
JF - Human Genetics
SN - 0340-6717
IS - 1
ER -