Abstract
We have identified a polymorphic compound dinucleotide repeat sequence in intron 1 of the β-amyloid precursor protein (APP) gene on chromosome 21. Using polymerase chain reaction (PCR) amplification of the locus, designated APPivsl, we detected 13 alleles in the CEPH family members (heterozygosity = 0.69). Lod score analysis showed complete linkage of the marker to the loci D21S210 and D21221.
Original language | English (US) |
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Pages (from-to) | 85-86 |
Number of pages | 2 |
Journal | Human Genetics |
Volume | 93 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1994 |
Externally published | Yes |
ASJC Scopus subject areas
- Genetics(clinical)
- Genetics