Highly efficient one-pot multienzyme (OPME) synthesis of glycans with fluorous-tag assisted purification

Joel Hwang, Hai Yu, Hamed Malekan, Go Sugiarto, Yanhong Li, Jingyao Qu, Van Nguyen, Dongyuan Wu, Chen Xi

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Oligo(ethylene glycol)-linked light fluorous tags have been found to be optimal for conjugating to glycans for both high-yield enzymatic glycosylation reactions using one-pot multienzyme (OPME) systems and quick product purification using fluorous solid-phase extraction (FSPE) cartridges. The combination of OPME glycosylation systems and the FSPE cartridge purification scheme provides a highly effective strategy for facile synthesis and purification of glycans.

Original languageEnglish (US)
Pages (from-to)3159-3162
Number of pages4
JournalChemical Communications
Volume50
Issue number24
DOIs
StatePublished - Feb 25 2014

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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