Highly efficient chemoenzymatic synthesis of naturally occurring and non-natural α-2,6-linked sialosides: A P. damsela α-2,6- sialyltransferase with extremely flexible donor-substrate specificity

Hai Yu, Shengshu Huang, Harshal Chokhawala, Mingchi Sun, Haojie Zheng, Xi Chen

Research output: Contribution to journalArticlepeer-review

163 Scopus citations

Abstract

(Chemical Equation Presented) Just relax: A one-pot, three-enzyme chemoenzymatic synthetic approach is highly efficient for obtaining complex sialosides that contain diverse naturally occurring sialic acid modifications. α-2,6-Linked sialosides containing twelve naturally occurring sialic acid forms and seven non-natural sialic acid forms have been obtained.

Original languageEnglish (US)
Pages (from-to)3938-3944
Number of pages7
JournalAngewandte Chemie - International Edition
Volume45
Issue number24
DOIs
StatePublished - Jun 12 2006

Keywords

  • Carbohydrates
  • Chemoenzymatic synthesis
  • Enzyme catalysis
  • Sialic acids
  • Transferases

ASJC Scopus subject areas

  • Chemistry(all)

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