Highly efficient chemoenzymatic synthesis of β1-3-linked galactosides

Hai Yu; Vireak Thon; Kam Lau; Li Cai; Yi Chen; Shengmao Mu; Yanhong Li; Peng George Wang; Xi Chen

doi:10.1039/c0cc02850a

Highly efficient chemoenzymatic synthesis of β1-3-linked galactosides

Hai Yu, Vireak Thon, Kam Lau, Li Cai, Yi Chen, Shengmao Mu, Yanhong Li, Peng George Wang, Xi Chen

Chemistry

Research output: Contribution to journal › Article

47 Scopus citations

Abstract

A novel d-galactosyl-β1-3-N-acetyl-d-hexosamine phosphorylase cloned from Bifidobacterium infantis (BiGalHexNAcP) was used with a recombinant E. coli K-12 galactokinase (GalK) for efficient one-pot two-enzyme synthesis of T-antigens, galacto-N-biose (Galβ1-3GalNAc), lacto-N-biose (Galβ1-3GlcNAc), and their derivatives.

Original language	English (US)
Pages (from-to)	7507-7509
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	40
DOIs	https://doi.org/10.1039/c0cc02850a
Publication status	Published - Oct 28 2010

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ASJC Scopus subject areas

Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Catalysis
Chemistry(all)

Cite this

Yu, H., Thon, V., Lau, K., Cai, L., Chen, Y., Mu, S., ... Chen, X. (2010). Highly efficient chemoenzymatic synthesis of β1-3-linked galactosides. Chemical Communications, 46(40), 7507-7509. https://doi.org/10.1039/c0cc02850a

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abstract = "A novel d-galactosyl-β1-3-N-acetyl-d-hexosamine phosphorylase cloned from Bifidobacterium infantis (BiGalHexNAcP) was used with a recombinant E. coli K-12 galactokinase (GalK) for efficient one-pot two-enzyme synthesis of T-antigens, galacto-N-biose (Galβ1-3GalNAc), lacto-N-biose (Galβ1-3GlcNAc), and their derivatives.",

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AU - Thon, Vireak

AU - Lau, Kam

AU - Cai, Li

AU - Chen, Yi

AU - Mu, Shengmao

AU - Li, Yanhong

AU - Wang, Peng George

AU - Chen, Xi

PY - 2010/10/28

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Access to Document

10.1039/c0cc02850a