Highly efficient chemoenzymatic synthesis of β1-3-linked galactosides

Hai Yu; Vireak Thon; Kam Lau; Li Cai; Yi Chen; Shengmao Mu; Yanhong Li; Peng George Wang; Xi Chen

doi:10.1039/c0cc02850a

Highly efficient chemoenzymatic synthesis of β1-3-linked galactosides

Hai Yu, Vireak Thon, Kam Lau, Li Cai, Yi Chen, Shengmao Mu, Yanhong Li, Peng George Wang, Xi Chen

Chemistry

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

A novel d-galactosyl-β1-3-N-acetyl-d-hexosamine phosphorylase cloned from Bifidobacterium infantis (BiGalHexNAcP) was used with a recombinant E. coli K-12 galactokinase (GalK) for efficient one-pot two-enzyme synthesis of T-antigens, galacto-N-biose (Galβ1-3GalNAc), lacto-N-biose (Galβ1-3GlcNAc), and their derivatives.

Original language	English (US)
Pages (from-to)	7507-7509
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	40
DOIs	https://doi.org/10.1039/c0cc02850a
State	Published - Oct 28 2010

ASJC Scopus subject areas

Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Catalysis
Chemistry(all)

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title = "Highly efficient chemoenzymatic synthesis of β1-3-linked galactosides",

abstract = "A novel d-galactosyl-β1-3-N-acetyl-d-hexosamine phosphorylase cloned from Bifidobacterium infantis (BiGalHexNAcP) was used with a recombinant E. coli K-12 galactokinase (GalK) for efficient one-pot two-enzyme synthesis of T-antigens, galacto-N-biose (Galβ1-3GalNAc), lacto-N-biose (Galβ1-3GlcNAc), and their derivatives.",

author = "Hai Yu and Vireak Thon and Kam Lau and Li Cai and Yi Chen and Shengmao Mu and Yanhong Li and Wang, {Peng George} and Xi Chen",

year = "2010",

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language = "English (US)",

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pages = "7507--7509",

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T1 - Highly efficient chemoenzymatic synthesis of β1-3-linked galactosides

AU - Yu, Hai

AU - Thon, Vireak

AU - Lau, Kam

AU - Cai, Li

AU - Chen, Yi

AU - Mu, Shengmao

AU - Li, Yanhong

AU - Wang, Peng George

AU - Chen, Xi

PY - 2010/10/28

Y1 - 2010/10/28

N2 - A novel d-galactosyl-β1-3-N-acetyl-d-hexosamine phosphorylase cloned from Bifidobacterium infantis (BiGalHexNAcP) was used with a recombinant E. coli K-12 galactokinase (GalK) for efficient one-pot two-enzyme synthesis of T-antigens, galacto-N-biose (Galβ1-3GalNAc), lacto-N-biose (Galβ1-3GlcNAc), and their derivatives.

AB - A novel d-galactosyl-β1-3-N-acetyl-d-hexosamine phosphorylase cloned from Bifidobacterium infantis (BiGalHexNAcP) was used with a recombinant E. coli K-12 galactokinase (GalK) for efficient one-pot two-enzyme synthesis of T-antigens, galacto-N-biose (Galβ1-3GalNAc), lacto-N-biose (Galβ1-3GlcNAc), and their derivatives.

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DO - 10.1039/c0cc02850a

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SP - 7507

EP - 7509

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

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