Abstract
Background and objectives: Serum creatinine concentrations tend to be higher in black than white individuals and people of other races or ethnicities. These differences have been assumed to be largely related to race-related differences in body composition, especially muscle mass. Design, setting, participants, & measurements: In a diverse population of hemodialysis patients, we compared mean serum creatinine concentrations in black versus nonblack patients, adjusting for case mix (age, gender, diabetes, and dialysis vintage), body size (height, weight), laboratory parameters of nutritional status (albumin, predialysis blood urea nitrogen, transferrin, phosphorus, glucose), dialysis dosage (urea reduction ratio), and parameters of bioelectrical impedance (resistance and reactance), proxies for body composition. Results: Adjusted mean serum creatinine concentrations were significantly higher in black versus nonblack patients (11.7 versus 10.0 mg/dI; P < 0.0001). Black patients were roughly four-fold more likely to have a serum creatinine concentration >10 mg/dI and six-fold more likely to have a serum creatinine concentration >15 mg/dI. Higher serum creatinine concentrations were associated with a lower relative risk for death (0.93; 95% confidence interval 0.88 to 0.98 per mg/di); the association was slightly more pronounced among nonblack patients. Conclusions: Serum creatinine concentrations are significantly higher in black compared with nonblack emodialysis patients; these differences are not readily explained by differences in nutritional status or body composition.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 992-997 |
| Number of pages | 6 |
| Journal | Clinical Journal of the American Society of Nephrology |
| Volume | 3 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 2008 |
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ASJC Scopus subject areas
- Nephrology
- Transplantation
- Epidemiology
- Critical Care and Intensive Care Medicine
Cite this
Higher serum creatinine concentrations in black patients with chronic kidney disease : Beyond nutritional status and body composition. / Hsu, Joy; Johansen, Kirsten L.; Hsu, Chi Yuan; Kaysen, George; Chertow, Glenn M.
In: Clinical Journal of the American Society of Nephrology, Vol. 3, No. 4, 07.2008, p. 992-997.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Higher serum creatinine concentrations in black patients with chronic kidney disease
T2 - Beyond nutritional status and body composition
AU - Hsu, Joy
AU - Johansen, Kirsten L.
AU - Hsu, Chi Yuan
AU - Kaysen, George
AU - Chertow, Glenn M.
PY - 2008/7
Y1 - 2008/7
N2 - Background and objectives: Serum creatinine concentrations tend to be higher in black than white individuals and people of other races or ethnicities. These differences have been assumed to be largely related to race-related differences in body composition, especially muscle mass. Design, setting, participants, & measurements: In a diverse population of hemodialysis patients, we compared mean serum creatinine concentrations in black versus nonblack patients, adjusting for case mix (age, gender, diabetes, and dialysis vintage), body size (height, weight), laboratory parameters of nutritional status (albumin, predialysis blood urea nitrogen, transferrin, phosphorus, glucose), dialysis dosage (urea reduction ratio), and parameters of bioelectrical impedance (resistance and reactance), proxies for body composition. Results: Adjusted mean serum creatinine concentrations were significantly higher in black versus nonblack patients (11.7 versus 10.0 mg/dI; P < 0.0001). Black patients were roughly four-fold more likely to have a serum creatinine concentration >10 mg/dI and six-fold more likely to have a serum creatinine concentration >15 mg/dI. Higher serum creatinine concentrations were associated with a lower relative risk for death (0.93; 95% confidence interval 0.88 to 0.98 per mg/di); the association was slightly more pronounced among nonblack patients. Conclusions: Serum creatinine concentrations are significantly higher in black compared with nonblack emodialysis patients; these differences are not readily explained by differences in nutritional status or body composition.
AB - Background and objectives: Serum creatinine concentrations tend to be higher in black than white individuals and people of other races or ethnicities. These differences have been assumed to be largely related to race-related differences in body composition, especially muscle mass. Design, setting, participants, & measurements: In a diverse population of hemodialysis patients, we compared mean serum creatinine concentrations in black versus nonblack patients, adjusting for case mix (age, gender, diabetes, and dialysis vintage), body size (height, weight), laboratory parameters of nutritional status (albumin, predialysis blood urea nitrogen, transferrin, phosphorus, glucose), dialysis dosage (urea reduction ratio), and parameters of bioelectrical impedance (resistance and reactance), proxies for body composition. Results: Adjusted mean serum creatinine concentrations were significantly higher in black versus nonblack patients (11.7 versus 10.0 mg/dI; P < 0.0001). Black patients were roughly four-fold more likely to have a serum creatinine concentration >10 mg/dI and six-fold more likely to have a serum creatinine concentration >15 mg/dI. Higher serum creatinine concentrations were associated with a lower relative risk for death (0.93; 95% confidence interval 0.88 to 0.98 per mg/di); the association was slightly more pronounced among nonblack patients. Conclusions: Serum creatinine concentrations are significantly higher in black compared with nonblack emodialysis patients; these differences are not readily explained by differences in nutritional status or body composition.
UR - http://www.scopus.com/inward/record.url?scp=49149119241&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49149119241&partnerID=8YFLogxK
U2 - 10.2215/CJN.00090108
DO - 10.2215/CJN.00090108
M3 - Article
C2 - 18417750
AN - SCOPUS:49149119241
VL - 3
SP - 992
EP - 997
JO - Clinical Journal of the American Society of Nephrology
JF - Clinical Journal of the American Society of Nephrology
SN - 1555-9041
IS - 4
ER -