High-throughput protein binding end-points and kinetics in microarrays using label-free OI-RD microscopes

J. P. Landry, Y. S. Sun, Y. Y. Fei, Kit Lam, X. D. Zhu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The potential of biomolecular microarrays on glass for high-throughput kinetics assays has not previously been fully exploited. We demonstrate real-time label-free optical detection of antibodies binding to drug-antigen microarrays using oblique-incidence reflectivity difference (OI-RD) microscopes.

Original languageEnglish (US)
Title of host publicationOptics InfoBase Conference Papers
PublisherOptical Society of America
ISBN (Print)9781557528599
StatePublished - 2008
EventConference on Lasers and Electro-Optics, CLEO 2008 - San Jose, CA, United States
Duration: May 4 2008May 9 2008

Other

OtherConference on Lasers and Electro-Optics, CLEO 2008
CountryUnited States
CitySan Jose, CA
Period5/4/085/9/08

Fingerprint

antigens
Microarrays
antibodies
Labels
drugs
Microscopes
incidence
microscopes
Throughput
proteins
reflectance
Kinetics
glass
kinetics
Antigens
Antibodies
Assays
Glass
Protein Binding

ASJC Scopus subject areas

  • Instrumentation
  • Atomic and Molecular Physics, and Optics

Cite this

Landry, J. P., Sun, Y. S., Fei, Y. Y., Lam, K., & Zhu, X. D. (2008). High-throughput protein binding end-points and kinetics in microarrays using label-free OI-RD microscopes. In Optics InfoBase Conference Papers Optical Society of America.

High-throughput protein binding end-points and kinetics in microarrays using label-free OI-RD microscopes. / Landry, J. P.; Sun, Y. S.; Fei, Y. Y.; Lam, Kit; Zhu, X. D.

Optics InfoBase Conference Papers. Optical Society of America, 2008.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Landry, JP, Sun, YS, Fei, YY, Lam, K & Zhu, XD 2008, High-throughput protein binding end-points and kinetics in microarrays using label-free OI-RD microscopes. in Optics InfoBase Conference Papers. Optical Society of America, Conference on Lasers and Electro-Optics, CLEO 2008, San Jose, CA, United States, 5/4/08.
Landry JP, Sun YS, Fei YY, Lam K, Zhu XD. High-throughput protein binding end-points and kinetics in microarrays using label-free OI-RD microscopes. In Optics InfoBase Conference Papers. Optical Society of America. 2008
Landry, J. P. ; Sun, Y. S. ; Fei, Y. Y. ; Lam, Kit ; Zhu, X. D. / High-throughput protein binding end-points and kinetics in microarrays using label-free OI-RD microscopes. Optics InfoBase Conference Papers. Optical Society of America, 2008.
@inproceedings{c328ea6ade8d4eb286b6e109076fc510,
title = "High-throughput protein binding end-points and kinetics in microarrays using label-free OI-RD microscopes",
abstract = "The potential of biomolecular microarrays on glass for high-throughput kinetics assays has not previously been fully exploited. We demonstrate real-time label-free optical detection of antibodies binding to drug-antigen microarrays using oblique-incidence reflectivity difference (OI-RD) microscopes.",
author = "Landry, {J. P.} and Sun, {Y. S.} and Fei, {Y. Y.} and Kit Lam and Zhu, {X. D.}",
year = "2008",
language = "English (US)",
isbn = "9781557528599",
booktitle = "Optics InfoBase Conference Papers",
publisher = "Optical Society of America",

}

TY - GEN

T1 - High-throughput protein binding end-points and kinetics in microarrays using label-free OI-RD microscopes

AU - Landry, J. P.

AU - Sun, Y. S.

AU - Fei, Y. Y.

AU - Lam, Kit

AU - Zhu, X. D.

PY - 2008

Y1 - 2008

N2 - The potential of biomolecular microarrays on glass for high-throughput kinetics assays has not previously been fully exploited. We demonstrate real-time label-free optical detection of antibodies binding to drug-antigen microarrays using oblique-incidence reflectivity difference (OI-RD) microscopes.

AB - The potential of biomolecular microarrays on glass for high-throughput kinetics assays has not previously been fully exploited. We demonstrate real-time label-free optical detection of antibodies binding to drug-antigen microarrays using oblique-incidence reflectivity difference (OI-RD) microscopes.

UR - http://www.scopus.com/inward/record.url?scp=84898635052&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898635052&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84898635052

SN - 9781557528599

BT - Optics InfoBase Conference Papers

PB - Optical Society of America

ER -