High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy

J. Li, Y. Ding, W. Xiao, K. Xiao, Joyce S Lee, U. Bhardwaj, Z. Zhu, P. Digiglio, Kit Lam, Tingrui Pan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

This paper reports a microfluidic enabled print-to-screen (P2S) platform, which can achieve low-cost, high-throughput, high-precision printing with plug-and-play disposable cartridge, as well as parallel screening with minimized crosstalk. The performance of the P2S platform is characterized and, using this platform, the cell-killing performance of 3-out-of-10 drug combinations towards ovarian cancer cell is, for the first time, studied and as a result, 15 out of 175 drug combinations are newly identified to exert potent cancer cell toxicity. This demonstrates the potent applicability of P2S platform for combinatorial chemotherapy, which can greatly speed up the entire cycle of drug cocktail discovery.

Original languageEnglish (US)
Title of host publication2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2236-2239
Number of pages4
ISBN (Print)9781479989553
DOIs
StatePublished - Aug 5 2015
Event18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 - Anchorage, United States
Duration: Jun 21 2015Jun 25 2015

Other

Other18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
CountryUnited States
CityAnchorage
Period6/21/156/25/15

Fingerprint

Chemotherapy
chemotherapy
platforms
Cells
Throughput
drugs
Crosstalk
Microfluidics
Toxicity
Printing
Screening
cancer
cartridges
plugs
crosstalk
printing
toxicity
Costs
screening
cycles

Keywords

  • cancer cells
  • combinatorial screening
  • hydrogel
  • Microfluidic
  • printing

ASJC Scopus subject areas

  • Instrumentation
  • Electrical and Electronic Engineering

Cite this

Li, J., Ding, Y., Xiao, W., Xiao, K., Lee, J. S., Bhardwaj, U., ... Pan, T. (2015). High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy. In 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 (pp. 2236-2239). [7181406] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/TRANSDUCERS.2015.7181406

High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy. / Li, J.; Ding, Y.; Xiao, W.; Xiao, K.; Lee, Joyce S; Bhardwaj, U.; Zhu, Z.; Digiglio, P.; Lam, Kit; Pan, Tingrui.

2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015. Institute of Electrical and Electronics Engineers Inc., 2015. p. 2236-2239 7181406.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Li, J, Ding, Y, Xiao, W, Xiao, K, Lee, JS, Bhardwaj, U, Zhu, Z, Digiglio, P, Lam, K & Pan, T 2015, High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy. in 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015., 7181406, Institute of Electrical and Electronics Engineers Inc., pp. 2236-2239, 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015, Anchorage, United States, 6/21/15. https://doi.org/10.1109/TRANSDUCERS.2015.7181406
Li J, Ding Y, Xiao W, Xiao K, Lee JS, Bhardwaj U et al. High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy. In 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015. Institute of Electrical and Electronics Engineers Inc. 2015. p. 2236-2239. 7181406 https://doi.org/10.1109/TRANSDUCERS.2015.7181406
Li, J. ; Ding, Y. ; Xiao, W. ; Xiao, K. ; Lee, Joyce S ; Bhardwaj, U. ; Zhu, Z. ; Digiglio, P. ; Lam, Kit ; Pan, Tingrui. / High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy. 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015. Institute of Electrical and Electronics Engineers Inc., 2015. pp. 2236-2239
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