High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy

J. Li, Y. Ding, W. Xiao, K. Xiao, Joyce S Lee, U. Bhardwaj, Z. Zhu, P. Digiglio, Kit Lam, Tingrui Pan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

This paper reports a microfluidic enabled print-to-screen (P2S) platform, which can achieve low-cost, high-throughput, high-precision printing with plug-and-play disposable cartridge, as well as parallel screening with minimized crosstalk. The performance of the P2S platform is characterized and, using this platform, the cell-killing performance of 3-out-of-10 drug combinations towards ovarian cancer cell is, for the first time, studied and as a result, 15 out of 175 drug combinations are newly identified to exert potent cancer cell toxicity. This demonstrates the potent applicability of P2S platform for combinatorial chemotherapy, which can greatly speed up the entire cycle of drug cocktail discovery.

Original languageEnglish (US)
Title of host publication2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2236-2239
Number of pages4
ISBN (Print)9781479989553
DOIs
StatePublished - Aug 5 2015
Event18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 - Anchorage, United States
Duration: Jun 21 2015Jun 25 2015

Other

Other18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
CountryUnited States
CityAnchorage
Period6/21/156/25/15

Keywords

  • cancer cells
  • combinatorial screening
  • hydrogel
  • Microfluidic
  • printing

ASJC Scopus subject areas

  • Instrumentation
  • Electrical and Electronic Engineering

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  • Cite this

    Li, J., Ding, Y., Xiao, W., Xiao, K., Lee, J. S., Bhardwaj, U., Zhu, Z., Digiglio, P., Lam, K., & Pan, T. (2015). High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy. In 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 (pp. 2236-2239). [7181406] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/TRANSDUCERS.2015.7181406