High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy

J. Li; Y. Ding; W. Xiao; K. Xiao; Joyce S Lee; U. Bhardwaj; Z. Zhu; P. Digiglio; Kit Lam; Tingrui Pan

doi:10.1109/TRANSDUCERS.2015.7181406

High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy

J. Li, Y. Ding, W. Xiao, K. Xiao, Joyce S Lee, U. Bhardwaj, Z. Zhu, P. Digiglio, Kit Lam, Tingrui Pan

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

This paper reports a microfluidic enabled print-to-screen (P2S) platform, which can achieve low-cost, high-throughput, high-precision printing with plug-and-play disposable cartridge, as well as parallel screening with minimized crosstalk. The performance of the P2S platform is characterized and, using this platform, the cell-killing performance of 3-out-of-10 drug combinations towards ovarian cancer cell is, for the first time, studied and as a result, 15 out of 175 drug combinations are newly identified to exert potent cancer cell toxicity. This demonstrates the potent applicability of P2S platform for combinatorial chemotherapy, which can greatly speed up the entire cycle of drug cocktail discovery.

Original language	English (US)
Title of host publication	2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	2236-2239
Number of pages	4
ISBN (Print)	9781479989553
DOIs	https://doi.org/10.1109/TRANSDUCERS.2015.7181406
State	Published - Aug 5 2015
Event	18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 - Anchorage, United States Duration: Jun 21 2015 → Jun 25 2015

Other

Other	18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
Country/Territory	United States
City	Anchorage
Period	6/21/15 → 6/25/15

Keywords

cancer cells
combinatorial screening
hydrogel
Microfluidic
printing

ASJC Scopus subject areas

Instrumentation
Electrical and Electronic Engineering

Access to Document

10.1109/TRANSDUCERS.2015.7181406

Cite this

Li, J., Ding, Y., Xiao, W., Xiao, K., Lee, J. S., Bhardwaj, U., Zhu, Z., Digiglio, P., Lam, K., & Pan, T. (2015). High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy. In 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 (pp. 2236-2239). [7181406] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/TRANSDUCERS.2015.7181406

High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy. / Li, J.; Ding, Y.; Xiao, W.; Xiao, K.; Lee, Joyce S; Bhardwaj, U.; Zhu, Z.; Digiglio, P.; Lam, Kit ; Pan, Tingrui.

2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015. Institute of Electrical and Electronics Engineers Inc., 2015. p. 2236-2239 7181406.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Li, J, Ding, Y, Xiao, W, Xiao, K, Lee, JS, Bhardwaj, U, Zhu, Z, Digiglio, P, Lam, K & Pan, T 2015, High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy. in 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015., 7181406, Institute of Electrical and Electronics Engineers Inc., pp. 2236-2239, 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015, Anchorage, United States, 6/21/15. https://doi.org/10.1109/TRANSDUCERS.2015.7181406

Li J, Ding Y, Xiao W, Xiao K, Lee JS, Bhardwaj U et al. High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy. In 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015. Institute of Electrical and Electronics Engineers Inc. 2015. p. 2236-2239. 7181406 https://doi.org/10.1109/TRANSDUCERS.2015.7181406

Li, J. ; Ding, Y. ; Xiao, W. ; Xiao, K. ; Lee, Joyce S ; Bhardwaj, U. ; Zhu, Z. ; Digiglio, P. ; Lam, Kit ; Pan, Tingrui. / High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy. 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015. Institute of Electrical and Electronics Engineers Inc., 2015. pp. 2236-2239

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abstract = "This paper reports a microfluidic enabled print-to-screen (P2S) platform, which can achieve low-cost, high-throughput, high-precision printing with plug-and-play disposable cartridge, as well as parallel screening with minimized crosstalk. The performance of the P2S platform is characterized and, using this platform, the cell-killing performance of 3-out-of-10 drug combinations towards ovarian cancer cell is, for the first time, studied and as a result, 15 out of 175 drug combinations are newly identified to exert potent cancer cell toxicity. This demonstrates the potent applicability of P2S platform for combinatorial chemotherapy, which can greatly speed up the entire cycle of drug cocktail discovery.",

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High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy

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