High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy

J. Li; Y. Ding; W. Xiao; K. Xiao; Joyce S Lee; U. Bhardwaj; Z. Zhu; P. Digiglio; Kit Lam; Tingrui Pan

doi:10.1109/TRANSDUCERS.2015.7181406

High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy

J. Li, Y. Ding, W. Xiao, K. Xiao, Joyce S Lee, U. Bhardwaj, Z. Zhu, P. Digiglio, Kit Lam, Tingrui Pan

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

This paper reports a microfluidic enabled print-to-screen (P2S) platform, which can achieve low-cost, high-throughput, high-precision printing with plug-and-play disposable cartridge, as well as parallel screening with minimized crosstalk. The performance of the P2S platform is characterized and, using this platform, the cell-killing performance of 3-out-of-10 drug combinations towards ovarian cancer cell is, for the first time, studied and as a result, 15 out of 175 drug combinations are newly identified to exert potent cancer cell toxicity. This demonstrates the potent applicability of P2S platform for combinatorial chemotherapy, which can greatly speed up the entire cycle of drug cocktail discovery.

Original language	English (US)
Title of host publication	2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	2236-2239
Number of pages	4
ISBN (Print)	9781479989553
DOIs	https://doi.org/10.1109/TRANSDUCERS.2015.7181406
State	Published - Aug 5 2015
Event	18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 - Anchorage, United States Duration: Jun 21 2015 → Jun 25 2015

Other

Other	18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
Country	United States
City	Anchorage
Period	6/21/15 → 6/25/15

Keywords

cancer cells
combinatorial screening
hydrogel
Microfluidic
printing

ASJC Scopus subject areas

Instrumentation
Electrical and Electronic Engineering

Access to Document

10.1109/TRANSDUCERS.2015.7181406

Fingerprint Dive into the research topics of 'High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy'. Together they form a unique fingerprint.

Cite this

Li, J., Ding, Y., Xiao, W., Xiao, K., Lee, J. S., Bhardwaj, U., Zhu, Z., Digiglio, P., Lam, K., & Pan, T. (2015). High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy. In 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 (pp. 2236-2239). [7181406] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/TRANSDUCERS.2015.7181406

High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy. / Li, J.; Ding, Y.; Xiao, W.; Xiao, K.; Lee, Joyce S; Bhardwaj, U.; Zhu, Z.; Digiglio, P.; Lam, Kit ; Pan, Tingrui.

2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015. Institute of Electrical and Electronics Engineers Inc., 2015. p. 2236-2239 7181406.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Li, J, Ding, Y, Xiao, W, Xiao, K, Lee, JS, Bhardwaj, U, Zhu, Z, Digiglio, P, Lam, K & Pan, T 2015, High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy. in 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015., 7181406, Institute of Electrical and Electronics Engineers Inc., pp. 2236-2239, 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015, Anchorage, United States, 6/21/15. https://doi.org/10.1109/TRANSDUCERS.2015.7181406

Li J, Ding Y, Xiao W, Xiao K, Lee JS, Bhardwaj U et al. High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy. In 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015. Institute of Electrical and Electronics Engineers Inc. 2015. p. 2236-2239. 7181406 https://doi.org/10.1109/TRANSDUCERS.2015.7181406

Li, J. ; Ding, Y. ; Xiao, W. ; Xiao, K. ; Lee, Joyce S ; Bhardwaj, U. ; Zhu, Z. ; Digiglio, P. ; Lam, Kit ; Pan, Tingrui. / High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy. 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015. Institute of Electrical and Electronics Engineers Inc., 2015. pp. 2236-2239

@inproceedings{d5a8d750275b413b841ca80c23643bed,

title = "High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy",

abstract = "This paper reports a microfluidic enabled print-to-screen (P2S) platform, which can achieve low-cost, high-throughput, high-precision printing with plug-and-play disposable cartridge, as well as parallel screening with minimized crosstalk. The performance of the P2S platform is characterized and, using this platform, the cell-killing performance of 3-out-of-10 drug combinations towards ovarian cancer cell is, for the first time, studied and as a result, 15 out of 175 drug combinations are newly identified to exert potent cancer cell toxicity. This demonstrates the potent applicability of P2S platform for combinatorial chemotherapy, which can greatly speed up the entire cycle of drug cocktail discovery.",

keywords = "cancer cells, combinatorial screening, hydrogel, Microfluidic, printing",

author = "J. Li and Y. Ding and W. Xiao and K. Xiao and Lee, {Joyce S} and U. Bhardwaj and Z. Zhu and P. Digiglio and Kit Lam and Tingrui Pan",

year = "2015",

month = aug,

day = "5",

doi = "10.1109/TRANSDUCERS.2015.7181406",

language = "English (US)",

isbn = "9781479989553",

pages = "2236--2239",

booktitle = "2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

note = "18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 ; Conference date: 21-06-2015 Through 25-06-2015",

}

TY - GEN

T1 - High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy

AU - Li, J.

AU - Ding, Y.

AU - Xiao, W.

AU - Xiao, K.

AU - Lee, Joyce S

AU - Bhardwaj, U.

AU - Zhu, Z.

AU - Digiglio, P.

AU - Lam, Kit

AU - Pan, Tingrui

PY - 2015/8/5

Y1 - 2015/8/5

N2 - This paper reports a microfluidic enabled print-to-screen (P2S) platform, which can achieve low-cost, high-throughput, high-precision printing with plug-and-play disposable cartridge, as well as parallel screening with minimized crosstalk. The performance of the P2S platform is characterized and, using this platform, the cell-killing performance of 3-out-of-10 drug combinations towards ovarian cancer cell is, for the first time, studied and as a result, 15 out of 175 drug combinations are newly identified to exert potent cancer cell toxicity. This demonstrates the potent applicability of P2S platform for combinatorial chemotherapy, which can greatly speed up the entire cycle of drug cocktail discovery.

AB - This paper reports a microfluidic enabled print-to-screen (P2S) platform, which can achieve low-cost, high-throughput, high-precision printing with plug-and-play disposable cartridge, as well as parallel screening with minimized crosstalk. The performance of the P2S platform is characterized and, using this platform, the cell-killing performance of 3-out-of-10 drug combinations towards ovarian cancer cell is, for the first time, studied and as a result, 15 out of 175 drug combinations are newly identified to exert potent cancer cell toxicity. This demonstrates the potent applicability of P2S platform for combinatorial chemotherapy, which can greatly speed up the entire cycle of drug cocktail discovery.

KW - cancer cells

KW - combinatorial screening

KW - hydrogel

KW - Microfluidic

KW - printing

UR - http://www.scopus.com/inward/record.url?scp=84955484389&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955484389&partnerID=8YFLogxK

U2 - 10.1109/TRANSDUCERS.2015.7181406

DO - 10.1109/TRANSDUCERS.2015.7181406

M3 - Conference contribution

AN - SCOPUS:84955484389

SN - 9781479989553

SP - 2236

EP - 2239

BT - 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015

Y2 - 21 June 2015 through 25 June 2015

ER -