Abstract
This paper reports a microfluidic enabled print-to-screen (P2S) platform, which can achieve low-cost, high-throughput, high-precision printing with plug-and-play disposable cartridge, as well as parallel screening with minimized crosstalk. The performance of the P2S platform is characterized and, using this platform, the cell-killing performance of 3-out-of-10 drug combinations towards ovarian cancer cell is, for the first time, studied and as a result, 15 out of 175 drug combinations are newly identified to exert potent cancer cell toxicity. This demonstrates the potent applicability of P2S platform for combinatorial chemotherapy, which can greatly speed up the entire cycle of drug cocktail discovery.
Original language | English (US) |
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Title of host publication | 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 |
Publisher | Institute of Electrical and Electronics Engineers Inc. |
Pages | 2236-2239 |
Number of pages | 4 |
ISBN (Print) | 9781479989553 |
DOIs | |
State | Published - Aug 5 2015 |
Event | 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 - Anchorage, United States Duration: Jun 21 2015 → Jun 25 2015 |
Other
Other | 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 |
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Country | United States |
City | Anchorage |
Period | 6/21/15 → 6/25/15 |
Keywords
- cancer cells
- combinatorial screening
- hydrogel
- Microfluidic
- printing
ASJC Scopus subject areas
- Instrumentation
- Electrical and Electronic Engineering