Abstract
This paper reports a microfluidic enabled print-to-screen (P2S) platform, which can achieve low-cost, high-throughput, high-precision printing with plug-and-play disposable cartridge, as well as parallel screening with minimized crosstalk. The performance of the P2S platform is characterized and, using this platform, the cell-killing performance of 3-out-of-10 drug combinations towards ovarian cancer cell is, for the first time, studied and as a result, 15 out of 175 drug combinations are newly identified to exert potent cancer cell toxicity. This demonstrates the potent applicability of P2S platform for combinatorial chemotherapy, which can greatly speed up the entire cycle of drug cocktail discovery.
| Original language | English (US) |
|---|---|
| Title of host publication | 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 |
| Publisher | Institute of Electrical and Electronics Engineers Inc. |
| Pages | 2236-2239 |
| Number of pages | 4 |
| ISBN (Print) | 9781479989553 |
| DOIs | |
| State | Published - Aug 5 2015 |
| Event | 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 - Anchorage, United States Duration: Jun 21 2015 → Jun 25 2015 |
Other
| Other | 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 |
|---|---|
| Country | United States |
| City | Anchorage |
| Period | 6/21/15 → 6/25/15 |
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Keywords
- cancer cells
- combinatorial screening
- hydrogel
- Microfluidic
- printing
ASJC Scopus subject areas
- Instrumentation
- Electrical and Electronic Engineering
Cite this
High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy. / Li, J.; Ding, Y.; Xiao, W.; Xiao, K.; Lee, Joyce S; Bhardwaj, U.; Zhu, Z.; Digiglio, P.; Lam, Kit; Pan, Tingrui.
2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015. Institute of Electrical and Electronics Engineers Inc., 2015. p. 2236-2239 7181406.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - High-throughput print-to-screen (P2S) platform for combinatorial chemotherapy
AU - Li, J.
AU - Ding, Y.
AU - Xiao, W.
AU - Xiao, K.
AU - Lee, Joyce S
AU - Bhardwaj, U.
AU - Zhu, Z.
AU - Digiglio, P.
AU - Lam, Kit
AU - Pan, Tingrui
PY - 2015/8/5
Y1 - 2015/8/5
N2 - This paper reports a microfluidic enabled print-to-screen (P2S) platform, which can achieve low-cost, high-throughput, high-precision printing with plug-and-play disposable cartridge, as well as parallel screening with minimized crosstalk. The performance of the P2S platform is characterized and, using this platform, the cell-killing performance of 3-out-of-10 drug combinations towards ovarian cancer cell is, for the first time, studied and as a result, 15 out of 175 drug combinations are newly identified to exert potent cancer cell toxicity. This demonstrates the potent applicability of P2S platform for combinatorial chemotherapy, which can greatly speed up the entire cycle of drug cocktail discovery.
AB - This paper reports a microfluidic enabled print-to-screen (P2S) platform, which can achieve low-cost, high-throughput, high-precision printing with plug-and-play disposable cartridge, as well as parallel screening with minimized crosstalk. The performance of the P2S platform is characterized and, using this platform, the cell-killing performance of 3-out-of-10 drug combinations towards ovarian cancer cell is, for the first time, studied and as a result, 15 out of 175 drug combinations are newly identified to exert potent cancer cell toxicity. This demonstrates the potent applicability of P2S platform for combinatorial chemotherapy, which can greatly speed up the entire cycle of drug cocktail discovery.
KW - cancer cells
KW - combinatorial screening
KW - hydrogel
KW - Microfluidic
KW - printing
UR - http://www.scopus.com/inward/record.url?scp=84955484389&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84955484389&partnerID=8YFLogxK
U2 - 10.1109/TRANSDUCERS.2015.7181406
DO - 10.1109/TRANSDUCERS.2015.7181406
M3 - Conference contribution
AN - SCOPUS:84955484389
SN - 9781479989553
SP - 2236
EP - 2239
BT - 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
PB - Institute of Electrical and Electronics Engineers Inc.
ER -