High-speed, ultrahigh resolution optical coherence tomography of the retina in Hunter syndrome

Michael K. Yoon, Royce W. Chen, Thomas R. Hedges, Vivek Srinivasan, Iwona Gorczynska, James G. Fujimoto, Maciej Wojtkowski, Joel S. Schuman, Jay S. Duker

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

A 42-year-old man with Hunter syndrome developed bilateral visual field loss. Visual field testing demonstrated bilateral ring scotomata that corresponded to areas of thinning seen on standard resolution optical coherence tomography. High-speed, ultrahigh resolution optical coherence tomography, capable of 3.5-micron axial resolution, showed a loss of photoreceptors outside the fovea and cystoid spaces within the inner nuclear, ganglion cell, and outer nuclear layers. These results were consistent with histopathologic features that have been reported previously in patients with Hunter syndrome. Optical coherence tomography could be used as a diagnostic modality to monitor patients with Hunter syndrome and to detect subclinical forms of disease.

Original languageEnglish (US)
Pages (from-to)423-428
Number of pages6
JournalOphthalmic Surgery Lasers and Imaging
Volume38
Issue number5
StatePublished - Sep 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

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    Yoon, M. K., Chen, R. W., Hedges, T. R., Srinivasan, V., Gorczynska, I., Fujimoto, J. G., Wojtkowski, M., Schuman, J. S., & Duker, J. S. (2007). High-speed, ultrahigh resolution optical coherence tomography of the retina in Hunter syndrome. Ophthalmic Surgery Lasers and Imaging, 38(5), 423-428.