High-speed ultra-high-resolution optical coherence tomography findings in hydroxychloroquine retinopathy

Julio A. Rodriguez-Padilla, Thomas R. Hedges, Bryan Monson, Vivek Srinivasan, Maciej Wojtkowski, Elias Reichel, Jay S. Duker, Joel S. Schuman, James G. Fujimoto

Research output: Contribution to journalArticlepeer-review

107 Scopus citations

Abstract

Objectives: To compare structural changes in the retina seen on high-speed ultra-high-resolution optical coherence tomography (hsUHR-OCT) with multifocal electroretinography (mfERG) and automated visual fields in patients receiving hydroxychloroquine. Methods: Fifteen patients receiving hydroxychloroquine were evaluated clinically with hsUHR-OCT, mfERG, and automated visual fields. Six age-matched subjects were imaged with hsUHR-OCT and served as controls. Results: Distinctive discontinuity of the perifoveal photoreceptor inner segment/outer segment junction and thinning of the outer nuclear layer were seen with hsUHR-OCT in patients with mild retinal toxic effects. Progression to complete loss of the inner segment/outer segment junction and hyperscattering at the outer segment level were seen in more advanced cases. The mfERG abnormalities correlated with the hsUHR-OCT findings. Asymptomatic patients had normal hsUHR-OCT and mfERG results. Conclusion: Distinctive abnormalities in the perifoveal photoreceptor inner segment/outer segment junction were seen on hsUHR-OCT in patients receiving hydroxychloroquine who also were symptomatic and had abnormalities on automated visual fields and mfERG.

Original languageEnglish (US)
Pages (from-to)775-780
Number of pages6
JournalArchives of Ophthalmology
Volume125
Issue number6
DOIs
StatePublished - Jun 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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