High speed imaging of retinal pathology using ultrahigh resolution spectral/fourier domain optical coherence tomography in the ophthalmology clinic

Tony Ko, Maciej Wojtkowski, Vivek Srinivasan, Jay Dukei, Joel Schuman, James Fujimoto

Research output: Contribution to journalConference article

Abstract

An ultrahigh resolution spectral domain optical coherence tomography (OCT) system capable of performing high speed imaging in the ophthalmology clinic has been developed. An OCT system using spectral/Fourier domain enables high speed imaging rates of up to 25,000 axial scans (A-scan) per second. Using a low threshold femtosecond Ti:sapphire laser light source, which can generate bandwidths of ∼125 nm at 800 nm, cross-sectional imaging of the retina with ∼3 μm axial resolution is possible. High speed imaging has been performed in the ophthalmology clinic on patients with various retinal pathologies using the ultrahigh resolution spectral domain OCT system. Hgh pixel density OCT images containing 1024 pixels and 2048 transverse lines (A-scans) can be acquired in 0.08 seconds, which represents a ∼100 fold improvement in imaging speed over previously reported time-domain ultrahigh resolution OCT systems. High speed imaging also enables three dimensional scanning and mapping of intraretinal architectural morphology with unprecedented resolution. High speed ultrahigh resolution OCT is a powerful tool for visualizing retinal pathologies, especially those involving the details of the photoreceptor segments; it will enable three-dimensional retinal imaging and the rendering of image information from volumetric data, and it has the potential to improve the early diagnosis of retinal diseases.

Original languageEnglish (US)
Article number13
Pages (from-to)72-78
Number of pages7
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume5690
DOIs
StatePublished - Jul 21 2005
Externally publishedYes
EventCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX - San Jose, CA, United States
Duration: Jan 23 2005Jan 26 2005

Keywords

  • Fourier-Domain OCT
  • Medical imaging
  • Ophthalmology
  • Optical Coherence Tomography

ASJC Scopus subject areas

  • Engineering(all)

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