High-resolution spiral CT of the breast at very low dose: Concept and feasibility considerations

Willi A. Kalender, Marcel Beister, John M Boone, Daniel Kolditz, Sabrina V. Vollmar, Michaela C C Weigel

Research output: Contribution to journalArticlepeer-review

101 Scopus citations


Objective Mammography, today's standard imaging approach, has deficits with respect to the superimposition of anatomical structures. Dedicated CT of the breast so far indicated that it can provide superior soft-tissue imaging, but that it still has significant limitations with respect to spatial resolution and dose. We have assessed novel dedicated breast CT technology. Methods Based on simulations and measurements we developed novel technology which uses direct-conversion CdTe material and photon-counting electronics with 100 μm detector element size for close to 100% dose efficiency. We assessed the potential for the imaging of microcalcifications of 100 to 200 μm diameter and soft-tissue lesions of 1 to 5 mm diameter by simulations at dose levels between 1 and 6 mGy. Results Microcalcifications of 150 μm and soft-tissue lesions of 2 mm diameter were found to be clearly detectable at an average glandular dose of 3 mGy. Separate displays are required for high-resolution microcalcification and for low-resolution soft-tissue analysis. Total CT data acquisition time will be below 10 s. Conclusion Dedicated breast CT may eventually provide comprehensive diagnostic assessment of microcalcifications and soft-tissue structures at dose levels equivalent to or below those of two-view screening mammography.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalEuropean Radiology
Issue number1
StatePublished - Jan 2012


  • Breast
  • Computed tomography (CT)
  • Dose efficiency
  • Image quality
  • Spatial resolution

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'High-resolution spiral CT of the breast at very low dose: Concept and feasibility considerations'. Together they form a unique fingerprint.

Cite this