High-resolution parathyroid sonography

Erik R Wisner, Dominique Penninck, David S. Biller, Edward C Feldman, Christiana Drake, Thomas G. Nyland

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


The purpose of this study was to assess the diagnostic utility of parathyroid ultrasonography to differentiate causes of hypercalcemia in dogs. We analyzed qualitative and quantitative ultrasound imaging findings and clinical pathology data from 33 dogs that underwent parathyroid ultrasound examination as part of the diagnostic evaluation for hypercalcemia. Diagnoses of the diseases causing hypercalcemia included parathyroid carcinoma (n = 5), parathyroid adenoma (n = 15), parathyroid adenomatous hyperplasia (n = 6), chronic renal insufficiency (n = 3), and hypercalcemia of malignancy (n = 4). All parathyroid lesions were round or oval and hypoechoic compared with surrounding thyroid parenchyma. Adenoma tous and adenocarcinomatous glands were 4 mm or larger in longest linear measurement on US examination and were statistically significantly larger than hyperplastic glands. (p < 0.001) Linear measurements of parathyroid glands acquired at the time of ultrasound examination correlated well with direct size determination after surgical excision. (r2 = 0.9, p < 0.0001) Parathyroid lesions ≥4 mm are highly suspicious for parathyroid adenoma or carcinoma, while US lesions <4 mm most likely represent primary adenomatous hyperplasia or secondary parathyroid hyperplasia. Parathyroid size estimation from ultrasound examination is an accurate predictor of true size. Veterinary Radiology & Ultrasound, Vol. 38, No, 6, 1997, pp 462-466.

Original languageEnglish (US)
Pages (from-to)462-466
Number of pages5
JournalVeterinary Radiology and Ultrasound
Issue number6
StatePublished - Nov 1997


  • Hyperparathyroidism
  • Parathyroid adenocarcinoma
  • Parathyroid adenoma
  • Parathyroid gland
  • Parathyroid hyperplasia
  • Ultrasound

ASJC Scopus subject areas

  • veterinary(all)


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