High resolution Fourier-domain optical coherence tomography of retinal angiomatous proliferation

Steven N. Truong, Suhail Alam, Robert Zawadzki, Stacey S. Choi, David G. Telander, Susanna Soon Chun Park, John S Werner, Lawrence S Morse

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


PURPOSE: To study the anatomic details of retinal angiomatous proliferation (RAP) in patients with age-related macular degeneration (AMD) using high-resolution Fourier-domain optical coherence tomography (Fd-OCT) and its three-dimensional reconstructions. METHODS: A Fd-OCT instrument was used to image five patients clinically diagnosed with RAP. A series of 100 raster-scanned B-scans centered over the macula was registered and rendered as a three-dimensional volume. These retinal structures were analyzed for anatomic details of the RAP lesions. RESULTS: The RAP lesion could be identified within the retina on Fd-OCT in all five cases. Fd-OCT images of the first four cases revealed areas of intraretinal neovascularization (IRN) in the deep retina adjacent to a pigment epithelial detachment (PED). There was neovascular proliferation anteriorly and posteriorly through a break in the retinal pigment epithelium (RPE). In three of the four cases, Bruch membrane remained intact. There was no identifiable choroidal neovascularization (CNV). The fifth case had both subretinal and sub-RPE neovascular membranes without a PED. CONCLUSION: Fd-OCT provides unprecedented in vivo detail of the anatomy of RAP lesions that nearly resembles histologic specimens. This study suggests that the initial neovascular process in RAP can originate either within the retina or in the sub-RPE space.

Original languageEnglish (US)
Pages (from-to)915-925
Number of pages11
Issue number7
StatePublished - Sep 2007


  • Chorioretinal anastomosis
  • Exudative age-related macular degeneration
  • Fourier-domain optical coherence tomography
  • High resolution optical coherence tomography
  • Intraretinal neovascularization
  • Retinal angiomatous proliferation
  • Staging system

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems


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