Abstract
PURPOSE. To investigate the use of high-resolution Fourierdomain optical coherence tomography (Fd-OCT) to image choroidal neovascular membranes (CNVMs) associated with exudative age-related macular degeneration (eAMD). METHODS. An Fd-OCT instrument with axial resolution of 4 to 4.5 μm and transverse resolution of 10 to 15 μm was used to image 21 eyes (19 subjects) with newly diagnosed eAMD. A raster series of 100 B-scans separated by 60 μm was used to study the growth pattern of CNVM and associated morphologic changes. CNVM size was determined using 250 to 300 serial virtual C-scans of reconstructed three-dimensional macular volume. RESULTS. A highly reflective subretinal and/or subretinal pigment epithelial (RPE) lesion that co-localized with the CNVM seen on fluorescein angiography was detected in all eyes by Fd-OCT. Although a combined subretinal and sub-RPE growth pattern of various degrees was noted in 15 (71%) eyes, a statistically significant difference in the distribution of growth pattern was noted when classic CNVM was compared with occult CNVM (X2= 10.4, df = 2, P < 0.005). Classic lesions had >90% subretinal growth pattern, whereas occult lesions had a more variable growth pattern. Angiographic CNVM size correlated with size on Fd-OCT but correlation was better for classic CNVM (classic, r = 0.99, P < 0.0001; nonclassic, r = 0.78, P < 0.001). CONCLUSIONS. Fd-OCT is a promising potential alternative modality to visualize CNVM with AMD. Angiographic lesion size and type correlated with growth pattern and size of CNVM on Fd-OCT, with correlation being stronger for classic lesions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4200-4206 |
| Number of pages | 7 |
| Journal | Investigative Ophthalmology and Visual Science |
| Volume | 51 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2010 |
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ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
- Medicine(all)
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High-resolution fourier-domain optical coherence tomography of choroidal neovascular membranes associated with age-related macular degeneration. / Park, Susanna Soon Chun; Truong, Steven N.; Zawadzki, Robert; Alam, Suhail; Choi, Stacey S.; Telander, David G.; Werner, John S; Morse, Lawrence S.
In: Investigative Ophthalmology and Visual Science, Vol. 51, No. 8, 08.2010, p. 4200-4206.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High-resolution fourier-domain optical coherence tomography of choroidal neovascular membranes associated with age-related macular degeneration
AU - Park, Susanna Soon Chun
AU - Truong, Steven N.
AU - Zawadzki, Robert
AU - Alam, Suhail
AU - Choi, Stacey S.
AU - Telander, David G.
AU - Werner, John S
AU - Morse, Lawrence S
PY - 2010/8
Y1 - 2010/8
N2 - PURPOSE. To investigate the use of high-resolution Fourierdomain optical coherence tomography (Fd-OCT) to image choroidal neovascular membranes (CNVMs) associated with exudative age-related macular degeneration (eAMD). METHODS. An Fd-OCT instrument with axial resolution of 4 to 4.5 μm and transverse resolution of 10 to 15 μm was used to image 21 eyes (19 subjects) with newly diagnosed eAMD. A raster series of 100 B-scans separated by 60 μm was used to study the growth pattern of CNVM and associated morphologic changes. CNVM size was determined using 250 to 300 serial virtual C-scans of reconstructed three-dimensional macular volume. RESULTS. A highly reflective subretinal and/or subretinal pigment epithelial (RPE) lesion that co-localized with the CNVM seen on fluorescein angiography was detected in all eyes by Fd-OCT. Although a combined subretinal and sub-RPE growth pattern of various degrees was noted in 15 (71%) eyes, a statistically significant difference in the distribution of growth pattern was noted when classic CNVM was compared with occult CNVM (X2= 10.4, df = 2, P < 0.005). Classic lesions had >90% subretinal growth pattern, whereas occult lesions had a more variable growth pattern. Angiographic CNVM size correlated with size on Fd-OCT but correlation was better for classic CNVM (classic, r = 0.99, P < 0.0001; nonclassic, r = 0.78, P < 0.001). CONCLUSIONS. Fd-OCT is a promising potential alternative modality to visualize CNVM with AMD. Angiographic lesion size and type correlated with growth pattern and size of CNVM on Fd-OCT, with correlation being stronger for classic lesions.
AB - PURPOSE. To investigate the use of high-resolution Fourierdomain optical coherence tomography (Fd-OCT) to image choroidal neovascular membranes (CNVMs) associated with exudative age-related macular degeneration (eAMD). METHODS. An Fd-OCT instrument with axial resolution of 4 to 4.5 μm and transverse resolution of 10 to 15 μm was used to image 21 eyes (19 subjects) with newly diagnosed eAMD. A raster series of 100 B-scans separated by 60 μm was used to study the growth pattern of CNVM and associated morphologic changes. CNVM size was determined using 250 to 300 serial virtual C-scans of reconstructed three-dimensional macular volume. RESULTS. A highly reflective subretinal and/or subretinal pigment epithelial (RPE) lesion that co-localized with the CNVM seen on fluorescein angiography was detected in all eyes by Fd-OCT. Although a combined subretinal and sub-RPE growth pattern of various degrees was noted in 15 (71%) eyes, a statistically significant difference in the distribution of growth pattern was noted when classic CNVM was compared with occult CNVM (X2= 10.4, df = 2, P < 0.005). Classic lesions had >90% subretinal growth pattern, whereas occult lesions had a more variable growth pattern. Angiographic CNVM size correlated with size on Fd-OCT but correlation was better for classic CNVM (classic, r = 0.99, P < 0.0001; nonclassic, r = 0.78, P < 0.001). CONCLUSIONS. Fd-OCT is a promising potential alternative modality to visualize CNVM with AMD. Angiographic lesion size and type correlated with growth pattern and size of CNVM on Fd-OCT, with correlation being stronger for classic lesions.
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U2 - 10.1167/iovs.09-4256
DO - 10.1167/iovs.09-4256
M3 - Article
C2 - 20220054
AN - SCOPUS:77955855979
VL - 51
SP - 4200
EP - 4206
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
SN - 0146-0404
IS - 8
ER -