High-Resolution Computed Tomography in Healthy Smokers and Never-Smokers

A 6-Year Follow-up Study of Men Born in 1933

J. Vikgren, M. Boijsen, K. Andelid, A. Ekberg-Jansson, S. Larsson, B. Bake, Ulf Tylen

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Purpose: To elucidate whether emphysematous lesions and other high-resolution computed tomography (HRCT) findings considered associated with smoking are part of a progressive process, and to measure the extent to which similar changes are found in never-smokers. Material and Methods: Healthy smokers and never-smokers were recruited from a randomized epidemiological study and investigated with a 6-year interval. Emphysema, parenchymal and subpleural nodules, ground-glass opacities, bronchial alterations, and septal lines were evaluated in 66 subjects (40 smokers, 11 of whom had stopped smoking in the interval, and 26 never-smokers), Lung function was tested. Results: All except emphysematous lesions were present to some extent in never-smokers. Emphysema, parenchymal nodules, and septal lines occurred significantly more in current smokers, and a progression in extent of emphysema, ground-glass opacities, bronchial alterations and septal lines was seen. There was no significant change among those who stopped and never-smokers except for bronchial alterations, which progressed in never-smokers. Conclusion: In healthy, elderly never-smokers a low extent of various HRCT findings has to be considered normal. Emphysema, parenchymal nodules, and ground-glass opacities are indicative of smoking-induced disease. Further progress may cease if smoking is stopped.

Original languageEnglish (US)
Pages (from-to)44-52
Number of pages9
JournalActa Radiologica
Volume45
Issue number1
StatePublished - Feb 2004
Externally publishedYes

Fingerprint

Emphysema
Smoking
Tomography
Glass
Process Assessment (Health Care)
Epidemiologic Studies
Lung

Keywords

  • Bronchiolitis
  • Computed tomography
  • Emphysema
  • Lung function
  • Smoking

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Vikgren, J., Boijsen, M., Andelid, K., Ekberg-Jansson, A., Larsson, S., Bake, B., & Tylen, U. (2004). High-Resolution Computed Tomography in Healthy Smokers and Never-Smokers: A 6-Year Follow-up Study of Men Born in 1933. Acta Radiologica, 45(1), 44-52.

High-Resolution Computed Tomography in Healthy Smokers and Never-Smokers : A 6-Year Follow-up Study of Men Born in 1933. / Vikgren, J.; Boijsen, M.; Andelid, K.; Ekberg-Jansson, A.; Larsson, S.; Bake, B.; Tylen, Ulf.

In: Acta Radiologica, Vol. 45, No. 1, 02.2004, p. 44-52.

Research output: Contribution to journalArticle

Vikgren, J, Boijsen, M, Andelid, K, Ekberg-Jansson, A, Larsson, S, Bake, B & Tylen, U 2004, 'High-Resolution Computed Tomography in Healthy Smokers and Never-Smokers: A 6-Year Follow-up Study of Men Born in 1933', Acta Radiologica, vol. 45, no. 1, pp. 44-52.
Vikgren J, Boijsen M, Andelid K, Ekberg-Jansson A, Larsson S, Bake B et al. High-Resolution Computed Tomography in Healthy Smokers and Never-Smokers: A 6-Year Follow-up Study of Men Born in 1933. Acta Radiologica. 2004 Feb;45(1):44-52.
Vikgren, J. ; Boijsen, M. ; Andelid, K. ; Ekberg-Jansson, A. ; Larsson, S. ; Bake, B. ; Tylen, Ulf. / High-Resolution Computed Tomography in Healthy Smokers and Never-Smokers : A 6-Year Follow-up Study of Men Born in 1933. In: Acta Radiologica. 2004 ; Vol. 45, No. 1. pp. 44-52.
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