High resolution blood flow mapping in the anterior segment of the eye

Dustin Kruse, Ronald Silverman, D. Jackson Coleman, Steven Erickson, Katherine Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

A new high frequency ultrasound system has been developed to visualize and measure blood flow parameters in the superficial microvasculature with a resolution of 40 μm. A recently reported method, which we call swept-scan or swept Doppler, has been developed to rapidly acquire 2-D frames data for blood velocity estimation using sweeping scans of a single element focused transducer. Using this new method combined with the M-mode technique, experiments were performed to quantify blood flow in the highly vascular, anterior segment of the eye. Scans of radial vessels in the rabbit iris indicate that blood flow can be mapped in arterioles down to 40 μm in diameter with velocities as low as 0.5 mm/sec. Furthermore, preliminary estimates of the effect of vasoactive drugs show that blood flow changes due to application of topical atropine can be measured in the 200 μm rabbit major arterial circle with both M-mode and swept-scan techniques. In particular, the M-mode technique was sufficiently sensitive to detect changes in peak systolic and diastolic blood flow, and these velocity measurements were consistent with those obtained from the swept-scan.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE Ultrasonics Symposium
PublisherIEEE
Pages1477-1480
Number of pages4
Volume2
StatePublished - 1999
Event1999 IEEE Ultrasonics Symposium - Caesars Tahoe, NV, USA
Duration: Oct 17 1999Oct 20 1999

Other

Other1999 IEEE Ultrasonics Symposium
CityCaesars Tahoe, NV, USA
Period10/17/9910/20/99

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Kruse, D., Silverman, R., Coleman, D. J., Erickson, S., & Ferrara, K. (1999). High resolution blood flow mapping in the anterior segment of the eye. In Proceedings of the IEEE Ultrasonics Symposium (Vol. 2, pp. 1477-1480). IEEE.