TY - JOUR
T1 - High resolution atlas of the venous brain vasculature from 7 T quantitative susceptibility maps
AU - Huck, Julia
AU - Wanner, Yvonne
AU - Fan, Audrey P.
AU - Jäger, Anna Thekla
AU - Grahl, Sophia
AU - Schneider, Uta
AU - Villringer, Arno
AU - Steele, Christopher J.
AU - Tardif, Christine L.
AU - Bazin, Pierre Louis
AU - Gauthier, Claudine J.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - The vascular organization of the human brain can determine neurological and neurophysiological functions, yet thus far it has not been comprehensively mapped. Aging and diseases such as dementia are known to be associated with changes to the vasculature and normative data could help detect these vascular changes in neuroimaging studies. Furthermore, given the well-known impact of venous vessels on the blood oxygen level dependent (BOLD) signal, information about the common location of veins could help detect biases in existing datasets. In this work, a quantitative atlas of the venous vasculature using quantitative susceptibility maps (QSM) acquired with a 0.6-mm isotropic resolution is presented. The Venous Neuroanatomy (VENAT) atlas was created from 5 repeated 7 Tesla MRI measurements in young and healthy volunteers (n = 20, 10 females, mean age = 25.1 ± 2.5 years) using a two-step registration method on 3D segmentations of the venous vasculature. This cerebral vein atlas includes the average vessel location, diameter (mean: 0.84 ± 0.33 mm) and curvature (0.11 ± 0.05 mm−1) from all participants and provides an in vivo measure of the angio-architectonic organization of the human brain and its variability. This atlas can be used as a basis to understand changes in the vasculature during aging and neurodegeneration, as well as vascular and physiological effects in neuroimaging.
AB - The vascular organization of the human brain can determine neurological and neurophysiological functions, yet thus far it has not been comprehensively mapped. Aging and diseases such as dementia are known to be associated with changes to the vasculature and normative data could help detect these vascular changes in neuroimaging studies. Furthermore, given the well-known impact of venous vessels on the blood oxygen level dependent (BOLD) signal, information about the common location of veins could help detect biases in existing datasets. In this work, a quantitative atlas of the venous vasculature using quantitative susceptibility maps (QSM) acquired with a 0.6-mm isotropic resolution is presented. The Venous Neuroanatomy (VENAT) atlas was created from 5 repeated 7 Tesla MRI measurements in young and healthy volunteers (n = 20, 10 females, mean age = 25.1 ± 2.5 years) using a two-step registration method on 3D segmentations of the venous vasculature. This cerebral vein atlas includes the average vessel location, diameter (mean: 0.84 ± 0.33 mm) and curvature (0.11 ± 0.05 mm−1) from all participants and provides an in vivo measure of the angio-architectonic organization of the human brain and its variability. This atlas can be used as a basis to understand changes in the vasculature during aging and neurodegeneration, as well as vascular and physiological effects in neuroimaging.
KW - Cerebral vasculature
KW - QSM, UHF-MRI
KW - Vein atlas
KW - Vein segmentation
KW - Venous vasculature
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U2 - 10.1007/s00429-019-01919-4
DO - 10.1007/s00429-019-01919-4
M3 - Article
C2 - 31278570
AN - SCOPUS:85068854036
VL - 224
SP - 2467
EP - 2485
JO - Brain Structure and Function
JF - Brain Structure and Function
SN - 1863-2653
IS - 7
ER -