Abstract
A global scan of transcription factor usage in the sea urchin embryo was carried out in the context of the Strongylocentrotus purpuratus genome sequencing project, and results from six individual studies are here considered. Transcript prevalence data were obtained for over 280 regulatory genes encoding sequence-specific transcription factors of every known family, but excluding genes encoding zinc finger proteins. This is a statistically inclusive proxy for the total "regulome" of the sea urchin genome. Close to 80% of the regulome is expressed at significant levels by the late gastrula stage. Most regulatory genes must be used repeatedly for different functions as development progresses. An evolutionary implication is that animal complexity at the stage when the regulome first evolved was far simpler than even the last common bilaterian ancestor, and is thus of deep antiquity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 27-34 |
| Number of pages | 8 |
| Journal | Developmental Biology |
| Volume | 300 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 1 2006 |
| Externally published | Yes |
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Keywords
- Indirect development
- Regulome
- Transcription factor usage
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology
- Cell Biology
Cite this
High regulatory gene use in sea urchin embryogenesis : Implications for bilaterian development and evolution. / Howard-Ashby, Meredith; Materna, Stefan C.; Brown, Charles; Tu, Qiang; Oliveri, Paola; Cameron, R. Andrew; Davidson, Eric H.
In: Developmental Biology, Vol. 300, No. 1, 01.12.2006, p. 27-34.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - High regulatory gene use in sea urchin embryogenesis
T2 - Implications for bilaterian development and evolution
AU - Howard-Ashby, Meredith
AU - Materna, Stefan C.
AU - Brown, Charles
AU - Tu, Qiang
AU - Oliveri, Paola
AU - Cameron, R. Andrew
AU - Davidson, Eric H.
PY - 2006/12/1
Y1 - 2006/12/1
N2 - A global scan of transcription factor usage in the sea urchin embryo was carried out in the context of the Strongylocentrotus purpuratus genome sequencing project, and results from six individual studies are here considered. Transcript prevalence data were obtained for over 280 regulatory genes encoding sequence-specific transcription factors of every known family, but excluding genes encoding zinc finger proteins. This is a statistically inclusive proxy for the total "regulome" of the sea urchin genome. Close to 80% of the regulome is expressed at significant levels by the late gastrula stage. Most regulatory genes must be used repeatedly for different functions as development progresses. An evolutionary implication is that animal complexity at the stage when the regulome first evolved was far simpler than even the last common bilaterian ancestor, and is thus of deep antiquity.
AB - A global scan of transcription factor usage in the sea urchin embryo was carried out in the context of the Strongylocentrotus purpuratus genome sequencing project, and results from six individual studies are here considered. Transcript prevalence data were obtained for over 280 regulatory genes encoding sequence-specific transcription factors of every known family, but excluding genes encoding zinc finger proteins. This is a statistically inclusive proxy for the total "regulome" of the sea urchin genome. Close to 80% of the regulome is expressed at significant levels by the late gastrula stage. Most regulatory genes must be used repeatedly for different functions as development progresses. An evolutionary implication is that animal complexity at the stage when the regulome first evolved was far simpler than even the last common bilaterian ancestor, and is thus of deep antiquity.
KW - Indirect development
KW - Regulome
KW - Transcription factor usage
UR - http://www.scopus.com/inward/record.url?scp=34547634659&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547634659&partnerID=8YFLogxK
U2 - 10.1016/j.ydbio.2006.10.016
DO - 10.1016/j.ydbio.2006.10.016
M3 - Review article
C2 - 17101125
AN - SCOPUS:34547634659
VL - 300
SP - 27
EP - 34
JO - Developmental Biology
JF - Developmental Biology
SN - 0012-1606
IS - 1
ER -