High plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis

R. K. Chaganti, I. Tolstykh, M. K. Javaid, T. Neogi, J. Torner, J. Curtis, P. Jacques, D. Felson, Nancy E Lane, M. C. Nevitt

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Background: Previous studies suggest that the antioxidants vitamins C and E may protect against development of knee osteoarthritis (OA). We examined the association of circulating levels of vitamin C and E with incident whole knee radiographic OA (WKROA). Methods: We performed a nested case-control study of incident WKROA in MOST, a cohort of 3,026 men and women aged 50-79 years with, or at high risk of, knee OA. Incident cases were knees without either tibiofemoral (TF) or patellofemoral (PF) OA at baseline that developed TF and/or PF OA by 30-month follow-up. Two control knees per case were selected from those eligible for WKROA that did not develop it. Vitamin C and E (alpha-tocopherol) assays were done on baseline supernatant plasma (PCA) and serum samples, respectively. We examined the association of gender-specific tertiles of vitamin C and E with incident WKROA using logistic regression with GEE, adjusting for age, gender, and obesity. Results: Subjects without WKROA at baseline who were in the highest tertile of vitamin C had a higher incidence of WKROA [adjusted OR=2.20 (95% CI: 1.12-4.33); P-value=0.021], with similar results for the highest tertile of vitamin E [adjusted OR=1.89 (1.02-3.50); P-value=0.042], compared to those in the lowest tertiles. P-values for the trend of vitamin C and E tertiles and incident WKROA were 0.019 and 0.030, respectively. Conclusions: Higher levels of circulating vitamin C and E did not provide protection against incident radiographic knee OA, and may be associated with an increased risk of knee OA.

Original languageEnglish (US)
Pages (from-to)190-196
Number of pages7
JournalOsteoarthritis and Cartilage
Volume22
Issue number2
DOIs
StatePublished - Feb 2014

Keywords

  • Antioxidants
  • Knee osteoarthritis
  • Vitamin C
  • Vitamin E

ASJC Scopus subject areas

  • Biomedical Engineering
  • Orthopedics and Sports Medicine
  • Rheumatology

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    Chaganti, R. K., Tolstykh, I., Javaid, M. K., Neogi, T., Torner, J., Curtis, J., Jacques, P., Felson, D., Lane, N. E., & Nevitt, M. C. (2014). High plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis. Osteoarthritis and Cartilage, 22(2), 190-196. https://doi.org/10.1016/j.joca.2013.11.008