High plasma levels of factor VIII: An important risk factor for isolated pulmonary embolism

Ferda Öner Erkekol, Arzu Ulu, Numan Numanoglu, Nejat Akar

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: The aim of the study was to investigate whether factor V Leiden and prothrombin G20210A mutations, elevated levels of factor VIII and factor IX are associated with pulmonary embolism (PE). Methods: Sixty-four patients with objectively documented PE and 64 control subjects were included in this study. The authors divided the 64 subjects with PE into those with PE and deep vein thrombosis (combined form of venous thromboembolism, n = 26) and those with PE without deep vein thrombosis (isolated PE n = 38). Results: There was no significant difference between the PE groups and the control subjects with regard to the presence of factor V Leiden and prothrombin mutations and elevated levels of factor IX. Using the 90th percentile measured in control subjects (P90 = 168 U/dL) as a cut-off point for factor VIII levels, the authors found an 11-fold increased risk for both isolated PE patients and patients with a combined form of venous thromboembolism who have factor VIII levels >168 U/dL compared with individuals having factor VIII levels below this cut-off point. The risk was not affected by adjustments for other possible risk factors. Conclusions: Elevated plasma factor VIII levels were found to be a significant, independent risk factor for PE.

Original languageEnglish (US)
Pages (from-to)70-74
Number of pages5
JournalRespirology
Volume11
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

Fingerprint

Factor VIII
Pulmonary Embolism
Factor IX
Venous Thromboembolism
Prothrombin
Venous Thrombosis
Mutation
Control Groups

Keywords

  • Factor IX
  • Factor V Leiden
  • Factor VIII
  • Prothrombin G20210A
  • Pulmonary embolism

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

High plasma levels of factor VIII : An important risk factor for isolated pulmonary embolism. / Öner Erkekol, Ferda; Ulu, Arzu; Numanoglu, Numan; Akar, Nejat.

In: Respirology, Vol. 11, No. 1, 01.2006, p. 70-74.

Research output: Contribution to journalArticle

Öner Erkekol, Ferda ; Ulu, Arzu ; Numanoglu, Numan ; Akar, Nejat. / High plasma levels of factor VIII : An important risk factor for isolated pulmonary embolism. In: Respirology. 2006 ; Vol. 11, No. 1. pp. 70-74.
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