High plasma homocysteine: A risk factor for arterial and venous thrombosis in patients with normal coagulation profiles

Kandice Kottke-Marchant, Ralph Green, Donald W. Jacobsen, Anjan Gupta, Susan R. Savon, Michelle Secic, Killian Robinson

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A high plasma homocysteine concentration is associated with premature vascular disease and thrombosis. The association between high homocysteine concentrations and thrombosis in patients with a normal coagulation profile is unknown. Sixty adults (37 men and 23 women, mean age 46 years) with documented thrombosis were compared with age- and sex-matched controls. Those with risk factors for thrombosis or abnormal coagulation profiles were excluded. Homocysteine concentrations were higher in cases than controls (21.8 ± 13.8 vs 11.0 ± 4.7 μmol/L, p < 0.001). A cut point for defining high homocysteine concentrations was determined at 13 μmol/L and conferred an increased odds ratio for thrombosis overall (7.8, 95% CI 3.0-20.2, p < 0.001) as well as in men (8.9, 95% CI 3.026.1; p < 0.001) and women (37.8, 95% CI 6.5-213.9; p < 0.01). A high plasma homocysteine is a risk factor for thrombosis in patients with a normal coagulation profile. This common abnormality should be sought in patients with otherwise unexplained thrombotic episodes.

Original languageEnglish (US)
Pages (from-to)239-244
Number of pages6
JournalClinical and Applied Thrombosis/Hemostasis
Volume3
Issue number4
StatePublished - Oct 1997
Externally publishedYes

Keywords

  • Clotting
  • Homocysteine
  • Thrombosis

ASJC Scopus subject areas

  • Hematology

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    Kottke-Marchant, K., Green, R., Jacobsen, D. W., Gupta, A., Savon, S. R., Secic, M., & Robinson, K. (1997). High plasma homocysteine: A risk factor for arterial and venous thrombosis in patients with normal coagulation profiles. Clinical and Applied Thrombosis/Hemostasis, 3(4), 239-244.