High level of arginine vasopressin and 7.5% NaCl/6% dextran-70 solution: cardiovascular and renal effects.

A. T. Cox, Hung S Ho, R. A. Gunther

Research output: Contribution to journalArticle

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Abstract

A marked diuresis has been observed following resuscitation of hypotensive hemorrhaged animals with small volume hypertonic saline/dextran (HSD), 7.5% NaCl/6% dextran-70. We tested the hypothesis that high arginine vasopressin (AVP) levels associated with severe hemorrhage may exacerbate the diuretic effect of HSD infusion in euvolemic sheep. Following AVP infusion, a significant bradycardia (55% of baseline) and decreased cardiac output (62% of baseline) was observed (p < or = .05). Urine output increased during AVP infusion (25.4 +/- 2.3 ml/20 min) compared to control group (10.5 +/- 1.0 ml/20 min) (p < or = .0001). With HSD volume expansion, urine flow in the AVP group was initially 1.7 times greater than the control group (104.8 +/- 10 ml/20 min vs. 60.2 +/- 15 ml/20 min) (p < or = .05). High serum levels of AVP (600 +/- 33 pg/ml) may contribute to the diuresis seen with HSD resuscitation and possibly contribute to the bradycardia observed with severe hemorrhage.

Original languageEnglish (US)
Pages (from-to)372-376
Number of pages5
JournalShock (Augusta, Ga.)
Volume1
Issue number5
StatePublished - May 1994

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dextran - saline drug combination
Arginine Vasopressin
Dextrans
Kidney
Diuresis
Bradycardia
Resuscitation
Urine
Hemorrhage
Control Groups
Diuretics
Cardiac Output
Sheep
Serum

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Physiology

Cite this

High level of arginine vasopressin and 7.5% NaCl/6% dextran-70 solution : cardiovascular and renal effects. / Cox, A. T.; Ho, Hung S; Gunther, R. A.

In: Shock (Augusta, Ga.), Vol. 1, No. 5, 05.1994, p. 372-376.

Research output: Contribution to journalArticle

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