Abstract
A marked diuresis has been observed following resuscitation of hypotensive hemorrhaged animals with small volume hypertonic saline/dextran (HSD), 7.5% NaCl/6% dextran-70. We tested the hypothesis that high arginine vasopressin (AVP) levels associated with severe hemorrhage may exacerbate the diuretic effect of HSD infusion in euvolemic sheep. Following AVP infusion, a significant bradycardia (55% of baseline) and decreased cardiac output (62% of baseline) was observed (p < or = .05). Urine output increased during AVP infusion (25.4 +/- 2.3 ml/20 min) compared to control group (10.5 +/- 1.0 ml/20 min) (p < or = .0001). With HSD volume expansion, urine flow in the AVP group was initially 1.7 times greater than the control group (104.8 +/- 10 ml/20 min vs. 60.2 +/- 15 ml/20 min) (p < or = .05). High serum levels of AVP (600 +/- 33 pg/ml) may contribute to the diuresis seen with HSD resuscitation and possibly contribute to the bradycardia observed with severe hemorrhage.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 372-376 |
| Number of pages | 5 |
| Journal | Shock (Augusta, Ga.) |
| Volume | 1 |
| Issue number | 5 |
| State | Published - May 1994 |
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ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
- Physiology
Cite this
High level of arginine vasopressin and 7.5% NaCl/6% dextran-70 solution : cardiovascular and renal effects. / Cox, A. T.; Ho, Hung S; Gunther, R. A.
In: Shock (Augusta, Ga.), Vol. 1, No. 5, 05.1994, p. 372-376.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High level of arginine vasopressin and 7.5% NaCl/6% dextran-70 solution
T2 - cardiovascular and renal effects.
AU - Cox, A. T.
AU - Ho, Hung S
AU - Gunther, R. A.
PY - 1994/5
Y1 - 1994/5
N2 - A marked diuresis has been observed following resuscitation of hypotensive hemorrhaged animals with small volume hypertonic saline/dextran (HSD), 7.5% NaCl/6% dextran-70. We tested the hypothesis that high arginine vasopressin (AVP) levels associated with severe hemorrhage may exacerbate the diuretic effect of HSD infusion in euvolemic sheep. Following AVP infusion, a significant bradycardia (55% of baseline) and decreased cardiac output (62% of baseline) was observed (p < or = .05). Urine output increased during AVP infusion (25.4 +/- 2.3 ml/20 min) compared to control group (10.5 +/- 1.0 ml/20 min) (p < or = .0001). With HSD volume expansion, urine flow in the AVP group was initially 1.7 times greater than the control group (104.8 +/- 10 ml/20 min vs. 60.2 +/- 15 ml/20 min) (p < or = .05). High serum levels of AVP (600 +/- 33 pg/ml) may contribute to the diuresis seen with HSD resuscitation and possibly contribute to the bradycardia observed with severe hemorrhage.
AB - A marked diuresis has been observed following resuscitation of hypotensive hemorrhaged animals with small volume hypertonic saline/dextran (HSD), 7.5% NaCl/6% dextran-70. We tested the hypothesis that high arginine vasopressin (AVP) levels associated with severe hemorrhage may exacerbate the diuretic effect of HSD infusion in euvolemic sheep. Following AVP infusion, a significant bradycardia (55% of baseline) and decreased cardiac output (62% of baseline) was observed (p < or = .05). Urine output increased during AVP infusion (25.4 +/- 2.3 ml/20 min) compared to control group (10.5 +/- 1.0 ml/20 min) (p < or = .0001). With HSD volume expansion, urine flow in the AVP group was initially 1.7 times greater than the control group (104.8 +/- 10 ml/20 min vs. 60.2 +/- 15 ml/20 min) (p < or = .05). High serum levels of AVP (600 +/- 33 pg/ml) may contribute to the diuresis seen with HSD resuscitation and possibly contribute to the bradycardia observed with severe hemorrhage.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028441580&partnerID=8YFLogxK
M3 - Article
C2 - 7538036
AN - SCOPUS:0028441580
VL - 1
SP - 372
EP - 376
JO - Shock
JF - Shock
SN - 1073-2322
IS - 5
ER -