Abstract
Background: High-intensity focused ultrasound (HIFU) is effective in producing faemostosis in injuries from organ lacerations and punctures in animals but has not been evaluated in impact injuries. Method: High-energy blows were applied to 11 heparinized and anesthetized pigs, resulting in solid organ injury. HIFU was applied to injuries via laparotomy. The animals were closed, administered saline, observed under general anesthesia for 3.6 ± 0.4 hours, reopened, and inspected, and abdominal free fluid was aspirated. Results: Organ hemostasis was achieved (mean ± SD) with 15 ± 6 minutes of HIFU treatment and 54 ± 3 minutes of operating time, and 18.8 ± 13.1 mL/kg of blood was recovered from the abdomen. One animal died from an untreated occult injury to a large vein. HIFU-treated sites were hemostatic at relaparotomy, with 8.6 ± 6.2 mL/kg abdominal serosanguinous fluid recovered. Conclusion: HIFU is effective in producing hemosiasis by direct treatment of injured parenchyma in blunt trauma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 152-156 |
| Number of pages | 5 |
| Journal | Journal of Trauma - Injury, Infection and Critical Care |
| Volume | 57 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2004 |
| Externally published | Yes |
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Keywords
- Blunt injury
- High-intensity focused ultrasound (HIFU)
- Solid organ injury
- Ultrasound
ASJC Scopus subject areas
- Surgery
- Critical Care and Intensive Care Medicine
Cite this
High-intensity ultrasound treatment of blunt abdominal solid organ injury : An animal model. / Cornejo, Carol J.; Vaezy, Shahram; Jurkovich, Gregory; Paun, Maria; Sharar, Sam R.; Martin, Roy W.
In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 57, No. 1, 01.01.2004, p. 152-156.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High-intensity ultrasound treatment of blunt abdominal solid organ injury
T2 - An animal model
AU - Cornejo, Carol J.
AU - Vaezy, Shahram
AU - Jurkovich, Gregory
AU - Paun, Maria
AU - Sharar, Sam R.
AU - Martin, Roy W.
PY - 2004/1/1
Y1 - 2004/1/1
N2 - Background: High-intensity focused ultrasound (HIFU) is effective in producing faemostosis in injuries from organ lacerations and punctures in animals but has not been evaluated in impact injuries. Method: High-energy blows were applied to 11 heparinized and anesthetized pigs, resulting in solid organ injury. HIFU was applied to injuries via laparotomy. The animals were closed, administered saline, observed under general anesthesia for 3.6 ± 0.4 hours, reopened, and inspected, and abdominal free fluid was aspirated. Results: Organ hemostasis was achieved (mean ± SD) with 15 ± 6 minutes of HIFU treatment and 54 ± 3 minutes of operating time, and 18.8 ± 13.1 mL/kg of blood was recovered from the abdomen. One animal died from an untreated occult injury to a large vein. HIFU-treated sites were hemostatic at relaparotomy, with 8.6 ± 6.2 mL/kg abdominal serosanguinous fluid recovered. Conclusion: HIFU is effective in producing hemosiasis by direct treatment of injured parenchyma in blunt trauma.
AB - Background: High-intensity focused ultrasound (HIFU) is effective in producing faemostosis in injuries from organ lacerations and punctures in animals but has not been evaluated in impact injuries. Method: High-energy blows were applied to 11 heparinized and anesthetized pigs, resulting in solid organ injury. HIFU was applied to injuries via laparotomy. The animals were closed, administered saline, observed under general anesthesia for 3.6 ± 0.4 hours, reopened, and inspected, and abdominal free fluid was aspirated. Results: Organ hemostasis was achieved (mean ± SD) with 15 ± 6 minutes of HIFU treatment and 54 ± 3 minutes of operating time, and 18.8 ± 13.1 mL/kg of blood was recovered from the abdomen. One animal died from an untreated occult injury to a large vein. HIFU-treated sites were hemostatic at relaparotomy, with 8.6 ± 6.2 mL/kg abdominal serosanguinous fluid recovered. Conclusion: HIFU is effective in producing hemosiasis by direct treatment of injured parenchyma in blunt trauma.
KW - Blunt injury
KW - High-intensity focused ultrasound (HIFU)
KW - Solid organ injury
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=4043154131&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4043154131&partnerID=8YFLogxK
U2 - 10.1097/01.TA.0000088009.93307.23
DO - 10.1097/01.TA.0000088009.93307.23
M3 - Article
VL - 57
SP - 152
EP - 156
JO - Journal of Trauma and Acute Care Surgery
JF - Journal of Trauma and Acute Care Surgery
SN - 2163-0755
IS - 1
ER -