High-intensity ultrasound treatment of blunt abdominal solid organ injury

An animal model

Carol J. Cornejo, Shahram Vaezy, Gregory Jurkovich, Maria Paun, Sam R. Sharar, Roy W. Martin

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: High-intensity focused ultrasound (HIFU) is effective in producing faemostosis in injuries from organ lacerations and punctures in animals but has not been evaluated in impact injuries. Method: High-energy blows were applied to 11 heparinized and anesthetized pigs, resulting in solid organ injury. HIFU was applied to injuries via laparotomy. The animals were closed, administered saline, observed under general anesthesia for 3.6 ± 0.4 hours, reopened, and inspected, and abdominal free fluid was aspirated. Results: Organ hemostasis was achieved (mean ± SD) with 15 ± 6 minutes of HIFU treatment and 54 ± 3 minutes of operating time, and 18.8 ± 13.1 mL/kg of blood was recovered from the abdomen. One animal died from an untreated occult injury to a large vein. HIFU-treated sites were hemostatic at relaparotomy, with 8.6 ± 6.2 mL/kg abdominal serosanguinous fluid recovered. Conclusion: HIFU is effective in producing hemosiasis by direct treatment of injured parenchyma in blunt trauma.

Original languageEnglish (US)
Pages (from-to)152-156
Number of pages5
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume57
Issue number1
DOIs
StatePublished - Jan 1 2004
Externally publishedYes

Fingerprint

Animal Models
Wounds and Injuries
Therapeutics
Lacerations
Hemostatics
Hemostasis
Punctures
Abdomen
Laparotomy
General Anesthesia
Veins
Swine

Keywords

  • Blunt injury
  • High-intensity focused ultrasound (HIFU)
  • Solid organ injury
  • Ultrasound

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

Cite this

High-intensity ultrasound treatment of blunt abdominal solid organ injury : An animal model. / Cornejo, Carol J.; Vaezy, Shahram; Jurkovich, Gregory; Paun, Maria; Sharar, Sam R.; Martin, Roy W.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 57, No. 1, 01.01.2004, p. 152-156.

Research output: Contribution to journalArticle

Cornejo, Carol J. ; Vaezy, Shahram ; Jurkovich, Gregory ; Paun, Maria ; Sharar, Sam R. ; Martin, Roy W. / High-intensity ultrasound treatment of blunt abdominal solid organ injury : An animal model. In: Journal of Trauma - Injury, Infection and Critical Care. 2004 ; Vol. 57, No. 1. pp. 152-156.
@article{cb531bf2d5b74e8a9f38fced9e416de6,
title = "High-intensity ultrasound treatment of blunt abdominal solid organ injury: An animal model",
abstract = "Background: High-intensity focused ultrasound (HIFU) is effective in producing faemostosis in injuries from organ lacerations and punctures in animals but has not been evaluated in impact injuries. Method: High-energy blows were applied to 11 heparinized and anesthetized pigs, resulting in solid organ injury. HIFU was applied to injuries via laparotomy. The animals were closed, administered saline, observed under general anesthesia for 3.6 ± 0.4 hours, reopened, and inspected, and abdominal free fluid was aspirated. Results: Organ hemostasis was achieved (mean ± SD) with 15 ± 6 minutes of HIFU treatment and 54 ± 3 minutes of operating time, and 18.8 ± 13.1 mL/kg of blood was recovered from the abdomen. One animal died from an untreated occult injury to a large vein. HIFU-treated sites were hemostatic at relaparotomy, with 8.6 ± 6.2 mL/kg abdominal serosanguinous fluid recovered. Conclusion: HIFU is effective in producing hemosiasis by direct treatment of injured parenchyma in blunt trauma.",
keywords = "Blunt injury, High-intensity focused ultrasound (HIFU), Solid organ injury, Ultrasound",
author = "Cornejo, {Carol J.} and Shahram Vaezy and Gregory Jurkovich and Maria Paun and Sharar, {Sam R.} and Martin, {Roy W.}",
year = "2004",
month = "1",
day = "1",
doi = "10.1097/01.TA.0000088009.93307.23",
language = "English (US)",
volume = "57",
pages = "152--156",
journal = "Journal of Trauma and Acute Care Surgery",
issn = "2163-0755",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - High-intensity ultrasound treatment of blunt abdominal solid organ injury

T2 - An animal model

AU - Cornejo, Carol J.

AU - Vaezy, Shahram

AU - Jurkovich, Gregory

AU - Paun, Maria

AU - Sharar, Sam R.

AU - Martin, Roy W.

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Background: High-intensity focused ultrasound (HIFU) is effective in producing faemostosis in injuries from organ lacerations and punctures in animals but has not been evaluated in impact injuries. Method: High-energy blows were applied to 11 heparinized and anesthetized pigs, resulting in solid organ injury. HIFU was applied to injuries via laparotomy. The animals were closed, administered saline, observed under general anesthesia for 3.6 ± 0.4 hours, reopened, and inspected, and abdominal free fluid was aspirated. Results: Organ hemostasis was achieved (mean ± SD) with 15 ± 6 minutes of HIFU treatment and 54 ± 3 minutes of operating time, and 18.8 ± 13.1 mL/kg of blood was recovered from the abdomen. One animal died from an untreated occult injury to a large vein. HIFU-treated sites were hemostatic at relaparotomy, with 8.6 ± 6.2 mL/kg abdominal serosanguinous fluid recovered. Conclusion: HIFU is effective in producing hemosiasis by direct treatment of injured parenchyma in blunt trauma.

AB - Background: High-intensity focused ultrasound (HIFU) is effective in producing faemostosis in injuries from organ lacerations and punctures in animals but has not been evaluated in impact injuries. Method: High-energy blows were applied to 11 heparinized and anesthetized pigs, resulting in solid organ injury. HIFU was applied to injuries via laparotomy. The animals were closed, administered saline, observed under general anesthesia for 3.6 ± 0.4 hours, reopened, and inspected, and abdominal free fluid was aspirated. Results: Organ hemostasis was achieved (mean ± SD) with 15 ± 6 minutes of HIFU treatment and 54 ± 3 minutes of operating time, and 18.8 ± 13.1 mL/kg of blood was recovered from the abdomen. One animal died from an untreated occult injury to a large vein. HIFU-treated sites were hemostatic at relaparotomy, with 8.6 ± 6.2 mL/kg abdominal serosanguinous fluid recovered. Conclusion: HIFU is effective in producing hemosiasis by direct treatment of injured parenchyma in blunt trauma.

KW - Blunt injury

KW - High-intensity focused ultrasound (HIFU)

KW - Solid organ injury

KW - Ultrasound

UR - http://www.scopus.com/inward/record.url?scp=4043154131&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4043154131&partnerID=8YFLogxK

U2 - 10.1097/01.TA.0000088009.93307.23

DO - 10.1097/01.TA.0000088009.93307.23

M3 - Article

VL - 57

SP - 152

EP - 156

JO - Journal of Trauma and Acute Care Surgery

JF - Journal of Trauma and Acute Care Surgery

SN - 2163-0755

IS - 1

ER -