High-intensity ultrasound treatment of blunt abdominal solid organ injury: An animal model

Carol J. Cornejo, Shahram Vaezy, Gregory Jurkovich, Maria Paun, Sam R. Sharar, Roy W. Martin

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Background: High-intensity focused ultrasound (HIFU) is effective in producing faemostosis in injuries from organ lacerations and punctures in animals but has not been evaluated in impact injuries. Method: High-energy blows were applied to 11 heparinized and anesthetized pigs, resulting in solid organ injury. HIFU was applied to injuries via laparotomy. The animals were closed, administered saline, observed under general anesthesia for 3.6 ± 0.4 hours, reopened, and inspected, and abdominal free fluid was aspirated. Results: Organ hemostasis was achieved (mean ± SD) with 15 ± 6 minutes of HIFU treatment and 54 ± 3 minutes of operating time, and 18.8 ± 13.1 mL/kg of blood was recovered from the abdomen. One animal died from an untreated occult injury to a large vein. HIFU-treated sites were hemostatic at relaparotomy, with 8.6 ± 6.2 mL/kg abdominal serosanguinous fluid recovered. Conclusion: HIFU is effective in producing hemosiasis by direct treatment of injured parenchyma in blunt trauma.

Original languageEnglish (US)
Pages (from-to)152-156
Number of pages5
JournalJournal of Trauma - Injury, Infection and Critical Care
Issue number1
StatePublished - Jan 1 2004
Externally publishedYes


  • Blunt injury
  • High-intensity focused ultrasound (HIFU)
  • Solid organ injury
  • Ultrasound

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine


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