High homocysteine, low folate, and low vitamin B6 concentrations

Anjan Gupta, Ali Moustapha, Donald W. Jacobsen, Marlene Goormastic, E. Murat Tuzcu, Robert Hobbs, James Young, Karen James, Patrick McCarthy, Frederick Van Lente, Ralph Green, Killian Robinson

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Background: A high plasma homocysteine concentration is a risk factor for atherosclerosis and thrombosis, which are major causes of morbidity and mortality in heart transplant patients. High homocysteine concentrations may be caused by lower folate and vitamin B6 levels. We hypothesized that these patients might have high homocysteine concentrations and low levels of folate and vitamin B6, which could contribute to the development of vascular complications. Methods: Total fasting plasma homocysteine was measured in 189 cardiac transplant recipients and in healthy controls, as were concentrations of folate, vitamin B12, vitamin B6, and creatinine. Results: Homocysteine concentrations were higher in recipients than controls (19.1±13.0 vs. 11.0±3.0 μmol/L, P<0.01), and hyperhomocysteinemia (>90th percentile for controls, 14.6 μmol/L) was seen in 68% of recipients (P<0.01). Folate and vitamin B6 concentrations were lower (5.9±4.2 vs. 7.9±4.2 pmol/L and 40±25 vs. 84±77 nmol/L, respectively; P<0.01 for both). Folate and vitamin B6 deficiencies were seen in 10.8% and 17.9% of recipients, respectively (P<0.01). Hyperhomocysteinemia was more frequent in patients with vascular complications after transplantation than in those without (79.2% vs. 63.8%, P<0.05). Conclusions: Elevated plasma homocysteine and deficiencies of folate and vitamin B6 are common in transplant recipients. A high homocysteine concentration was more common in patients with vascular complications. Prospective studies are now required to evaluate the role of these abnormalities as risk factors for the atherothrombotic complications of transplantation.

Original languageEnglish (US)
Pages (from-to)544-550
Number of pages7
JournalTransplantation
Volume65
Issue number4
DOIs
StatePublished - Feb 27 1998
Externally publishedYes

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Vitamin B 6
Homocysteine
Folic Acid
Vitamin B 6 Deficiency
Blood Vessels
Transplantation
Hyperhomocysteinemia
Vitamin B 12
Fasting
Creatinine
Atherosclerosis
Thrombosis
Prospective Studies
Morbidity
Transplants
Mortality

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Gupta, A., Moustapha, A., Jacobsen, D. W., Goormastic, M., Tuzcu, E. M., Hobbs, R., ... Robinson, K. (1998). High homocysteine, low folate, and low vitamin B6 concentrations. Transplantation, 65(4), 544-550. https://doi.org/10.1097/00007890-199802270-00016

High homocysteine, low folate, and low vitamin B6 concentrations. / Gupta, Anjan; Moustapha, Ali; Jacobsen, Donald W.; Goormastic, Marlene; Tuzcu, E. Murat; Hobbs, Robert; Young, James; James, Karen; McCarthy, Patrick; Van Lente, Frederick; Green, Ralph; Robinson, Killian.

In: Transplantation, Vol. 65, No. 4, 27.02.1998, p. 544-550.

Research output: Contribution to journalArticle

Gupta, A, Moustapha, A, Jacobsen, DW, Goormastic, M, Tuzcu, EM, Hobbs, R, Young, J, James, K, McCarthy, P, Van Lente, F, Green, R & Robinson, K 1998, 'High homocysteine, low folate, and low vitamin B6 concentrations', Transplantation, vol. 65, no. 4, pp. 544-550. https://doi.org/10.1097/00007890-199802270-00016
Gupta A, Moustapha A, Jacobsen DW, Goormastic M, Tuzcu EM, Hobbs R et al. High homocysteine, low folate, and low vitamin B6 concentrations. Transplantation. 1998 Feb 27;65(4):544-550. https://doi.org/10.1097/00007890-199802270-00016
Gupta, Anjan ; Moustapha, Ali ; Jacobsen, Donald W. ; Goormastic, Marlene ; Tuzcu, E. Murat ; Hobbs, Robert ; Young, James ; James, Karen ; McCarthy, Patrick ; Van Lente, Frederick ; Green, Ralph ; Robinson, Killian. / High homocysteine, low folate, and low vitamin B6 concentrations. In: Transplantation. 1998 ; Vol. 65, No. 4. pp. 544-550.
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abstract = "Background: A high plasma homocysteine concentration is a risk factor for atherosclerosis and thrombosis, which are major causes of morbidity and mortality in heart transplant patients. High homocysteine concentrations may be caused by lower folate and vitamin B6 levels. We hypothesized that these patients might have high homocysteine concentrations and low levels of folate and vitamin B6, which could contribute to the development of vascular complications. Methods: Total fasting plasma homocysteine was measured in 189 cardiac transplant recipients and in healthy controls, as were concentrations of folate, vitamin B12, vitamin B6, and creatinine. Results: Homocysteine concentrations were higher in recipients than controls (19.1±13.0 vs. 11.0±3.0 μmol/L, P<0.01), and hyperhomocysteinemia (>90th percentile for controls, 14.6 μmol/L) was seen in 68{\%} of recipients (P<0.01). Folate and vitamin B6 concentrations were lower (5.9±4.2 vs. 7.9±4.2 pmol/L and 40±25 vs. 84±77 nmol/L, respectively; P<0.01 for both). Folate and vitamin B6 deficiencies were seen in 10.8{\%} and 17.9{\%} of recipients, respectively (P<0.01). Hyperhomocysteinemia was more frequent in patients with vascular complications after transplantation than in those without (79.2{\%} vs. 63.8{\%}, P<0.05). Conclusions: Elevated plasma homocysteine and deficiencies of folate and vitamin B6 are common in transplant recipients. A high homocysteine concentration was more common in patients with vascular complications. Prospective studies are now required to evaluate the role of these abnormalities as risk factors for the atherothrombotic complications of transplantation.",
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T1 - High homocysteine, low folate, and low vitamin B6 concentrations

AU - Gupta, Anjan

AU - Moustapha, Ali

AU - Jacobsen, Donald W.

AU - Goormastic, Marlene

AU - Tuzcu, E. Murat

AU - Hobbs, Robert

AU - Young, James

AU - James, Karen

AU - McCarthy, Patrick

AU - Van Lente, Frederick

AU - Green, Ralph

AU - Robinson, Killian

PY - 1998/2/27

Y1 - 1998/2/27

N2 - Background: A high plasma homocysteine concentration is a risk factor for atherosclerosis and thrombosis, which are major causes of morbidity and mortality in heart transplant patients. High homocysteine concentrations may be caused by lower folate and vitamin B6 levels. We hypothesized that these patients might have high homocysteine concentrations and low levels of folate and vitamin B6, which could contribute to the development of vascular complications. Methods: Total fasting plasma homocysteine was measured in 189 cardiac transplant recipients and in healthy controls, as were concentrations of folate, vitamin B12, vitamin B6, and creatinine. Results: Homocysteine concentrations were higher in recipients than controls (19.1±13.0 vs. 11.0±3.0 μmol/L, P<0.01), and hyperhomocysteinemia (>90th percentile for controls, 14.6 μmol/L) was seen in 68% of recipients (P<0.01). Folate and vitamin B6 concentrations were lower (5.9±4.2 vs. 7.9±4.2 pmol/L and 40±25 vs. 84±77 nmol/L, respectively; P<0.01 for both). Folate and vitamin B6 deficiencies were seen in 10.8% and 17.9% of recipients, respectively (P<0.01). Hyperhomocysteinemia was more frequent in patients with vascular complications after transplantation than in those without (79.2% vs. 63.8%, P<0.05). Conclusions: Elevated plasma homocysteine and deficiencies of folate and vitamin B6 are common in transplant recipients. A high homocysteine concentration was more common in patients with vascular complications. Prospective studies are now required to evaluate the role of these abnormalities as risk factors for the atherothrombotic complications of transplantation.

AB - Background: A high plasma homocysteine concentration is a risk factor for atherosclerosis and thrombosis, which are major causes of morbidity and mortality in heart transplant patients. High homocysteine concentrations may be caused by lower folate and vitamin B6 levels. We hypothesized that these patients might have high homocysteine concentrations and low levels of folate and vitamin B6, which could contribute to the development of vascular complications. Methods: Total fasting plasma homocysteine was measured in 189 cardiac transplant recipients and in healthy controls, as were concentrations of folate, vitamin B12, vitamin B6, and creatinine. Results: Homocysteine concentrations were higher in recipients than controls (19.1±13.0 vs. 11.0±3.0 μmol/L, P<0.01), and hyperhomocysteinemia (>90th percentile for controls, 14.6 μmol/L) was seen in 68% of recipients (P<0.01). Folate and vitamin B6 concentrations were lower (5.9±4.2 vs. 7.9±4.2 pmol/L and 40±25 vs. 84±77 nmol/L, respectively; P<0.01 for both). Folate and vitamin B6 deficiencies were seen in 10.8% and 17.9% of recipients, respectively (P<0.01). Hyperhomocysteinemia was more frequent in patients with vascular complications after transplantation than in those without (79.2% vs. 63.8%, P<0.05). Conclusions: Elevated plasma homocysteine and deficiencies of folate and vitamin B6 are common in transplant recipients. A high homocysteine concentration was more common in patients with vascular complications. Prospective studies are now required to evaluate the role of these abnormalities as risk factors for the atherothrombotic complications of transplantation.

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