High-frequency ventilation compared to conventional positive-pressure ventilation in the treatment of hyaline membrane disease in primates

R. E. Bell, T. J. Kuehl, J. J. Coalson, N. B. Ackerman, Donald Null, M. B. Escobedo, B. A. Yoder, J. D. Cornish, L. Nalle, R. M. Skarin

Research output: Contribution to journalArticle

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Abstract

High-frequency ventilation (HFV) has been suggested as an alternative to conventional positive-pressure ventilation (PPV) in the treatment of infants with hyaline membrane disease (HMD). Using a previously validated primary model of HMD, 15 baboon fetuses were delivered at 75% of gestation and randomly assigned to 1 of 3 ventilator treatment groups: (a) PPV, (b) HFV delivered by an oscillator (HFO), or (c) HFV delivered by a flow interrupter (HFFI). All animals had clinical and radiographic evidence of HMD. At 96 h of life, all animals were sacrificed and clinical and pathological findings were analyzed. During the first 10 h of the experiment, the HFO animals required higher mean proximal airway pressures than either the HFFI or PPV groups. However, both the HFFI and HFO animals had higher Pao2/Pao2 ratios than the PPV controls, suggesting earlier saccular recruitment. Thus, HFV is as effective as PPV in the treatment of HMD in baboons. Whether it will decrease the risk of bronchopulmonary dysplasia is not known.

Original languageEnglish (US)
Pages (from-to)764-768
Number of pages5
JournalCritical Care Medicine
Volume12
Issue number9
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

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Hyaline Membrane Disease
High-Frequency Ventilation
Positive-Pressure Respiration
Primates
Papio
Therapeutics
Bronchopulmonary Dysplasia
Mechanical Ventilators
Fetus
Pressure
Pregnancy

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

High-frequency ventilation compared to conventional positive-pressure ventilation in the treatment of hyaline membrane disease in primates. / Bell, R. E.; Kuehl, T. J.; Coalson, J. J.; Ackerman, N. B.; Null, Donald; Escobedo, M. B.; Yoder, B. A.; Cornish, J. D.; Nalle, L.; Skarin, R. M.

In: Critical Care Medicine, Vol. 12, No. 9, 01.01.1984, p. 764-768.

Research output: Contribution to journalArticle

Bell, RE, Kuehl, TJ, Coalson, JJ, Ackerman, NB, Null, D, Escobedo, MB, Yoder, BA, Cornish, JD, Nalle, L & Skarin, RM 1984, 'High-frequency ventilation compared to conventional positive-pressure ventilation in the treatment of hyaline membrane disease in primates', Critical Care Medicine, vol. 12, no. 9, pp. 764-768. https://doi.org/10.1097/00003246-198409000-00017
Bell, R. E. ; Kuehl, T. J. ; Coalson, J. J. ; Ackerman, N. B. ; Null, Donald ; Escobedo, M. B. ; Yoder, B. A. ; Cornish, J. D. ; Nalle, L. ; Skarin, R. M. / High-frequency ventilation compared to conventional positive-pressure ventilation in the treatment of hyaline membrane disease in primates. In: Critical Care Medicine. 1984 ; Vol. 12, No. 9. pp. 764-768.
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