High-frequency oscillatory ventilation versus intermittent mandatory ventilation: Early hemodynamic effects in the premature baboon with hyaline membrane disease

John P. Kinsella, Dale R. Gerstmann, Reese H. Clark, Donald Null, W. Robert Morrow, A. Florentina Taylor, Robert A. Delemos

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We studied the hemodynamic consequences during the first 24 h of life in premature baboons (140 d) with hyaline membrane disease that were treated with high-frequency oscillatory ventilation (HFOV) or conventional intermittent mandatory ventilation (IMV). Cardiac output and organ blood flow were measured at three time-points using the radiolabeled microsphere technique. Seven of seven HFOV and six of eight IMV animals survivedjhe 24-h period. By design, initial mean airway pressure (Pa„) was higher in the HFOV group (p < 0.01). HFOV Paw was progressively reduced during the study period because of improving oxygenation as measured by the arterial to alveolar oxygen ratio. In contrast, it was necessary to increase Paw in the IMV animals to maintain the arterial to alveolar oxygen ratio. By 23 h, the IMV group required higher Pa„ than the HFOV group (p < 0.05) and had a lower arterial to alveolar oxygen ratio (p < 0.05). We found no significant differences in left ventricular output, effective systemic flow, organ blood flow, or central venous pressure between the two groups at 3, 8, or 23 h. The HFOV strategy used in our study resulted in significant improvement in oxygenation during the initial 24 h of treatment without adverse effect on left ventricular output, cerebral blood flow, or central venous jpressure. We conclude that when appropriate changes in Paw are made during HFOV in response to improvement in arterial oxgenation and changes in lung inflation as assessed by chest radiographs HFOV can be achieved without depressing cardiovascular dynamics more than during conventional therapy with IMV.

Original languageEnglish (US)
Pages (from-to)160-166
Number of pages7
JournalPediatric Research
Issue number2
StatePublished - Jan 1 1991
Externally publishedYes


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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