High frequency contrast imaging

Yang Sun, Dustin E. Kruse, Paul A. Dayton, Katherine W. Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Ultrasound contrast agents enhance echoes from the microvasculature and enable the visualization of flow in smaller vessels. Here, we optically and acoustically investigate the dynamics of a microbubble with 10 MHz ultrasound insonation. Results of a numerical evaluation of the modified Rayleigh-Plesset equation are used to predict the dynamics of a microbubble. From the optical observations of a single microbubble, nonlinear oscillation (such as subharmonic components), destruction and radiation force are observed. The maximum bubble expansion using a 20 cycle 10 MHz chirp with pressure up to 3.5 MPa has been tested with initial diameters ranging from 1.5 to 5 μm, resulting in a maximum diameter kept below 8 μm. Optical and acoustical experiments provide insight into the mechanisms of destruction, including fragmentation and acoustically-driven diffusion. High frequency pulse transmission may provide the opportunity to detect contrast echoes resulting from a single pulse, may be robust in the presence of tissue motion, and may provide the opportunity to incorporate high frequency ultrasound into destruction-replenishment techniques.

Original languageEnglish (US)
Title of host publicationProceedings - IEEE Ultrasonics Symposium
EditorsM.P. Yuhas
Number of pages4
StatePublished - 2004
Event2004 IEEE Ultrasonics Symposium - Montreal, Que., Canada
Duration: Aug 23 2004Aug 27 2004


Other2004 IEEE Ultrasonics Symposium
CityMontreal, Que.

ASJC Scopus subject areas

  • Engineering(all)


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