High-fat meals reduce 24-h circulating leptin concentrations in women

Peter J Havel, Raymond Townsend, Leslie Chaump, Karen Teff

Research output: Contribution to journalArticlepeer-review

222 Scopus citations


Leptin induces weight loss in rodents via its effects on food intake and energy expenditure. High-fat diets induce weight gain, but the mechanism is not well understood. Previous studies have not found an effect of dietary fat content on fasting leptin. There is a nocturnal increase of leptin, however, which is related to insulin responses to meals. We have reported that adipocyte glucose utilization is involved in insulin-induced leptin secretion in vitro. Accordingly, high-fat, low-carbohydrate (HF/LC) meals, which induce smaller insulin and glucose responses, would produce lower leptin concentrations than low-fat, high-carbohydrate (LF/HC) meals. Blood samples were collected every 30-60 min for 24 h from 19 normal-weight (BMI, 24.2 ± 0.7 kg/m2; percent body fat = 31 ± 1%) women on 2 days (10 days apart) during which the subjects were randomized to consume three isocaloric 730- kcal meals containing either 60/20 or 20/60% of energy as fat/carbohydrate. Overall insulin and glycemic responses (24-h area under the curve [AUC]) were reduced by 55 and 61%, respectively, on the HF/LC day (P < 0.0001). During LF/HC feeding, there were larger increases of leptin 4-6 h after breakfast (38 ± 7%, P < 0.001) and lunch (78 ± 14%, P < 0.001) than after HF/LC meals (both P < 0.02). During LF/HC feeding, leptin increased from a morning baseline of 10.7 ± 1.6 ng/ml to a nocturnal peak of 21.3 ± 1.3 ng/ml (change, 10.6 ± 1.3 ng/ml; percent change, 123 ± 16%;P < 0.0001). The amplitudes of the nocturnal rise of leptin and the 24-h leptin AUC were 21 ± 8% (P < 0.005) and 38 ± 12% (P < 0.0025) larger, respectively, on the LF/HC day. In summary, consumption of HF/LC meals results in lowered 24-h circulating leptin concentrations. This result may be a consequence of decreased adipocyte glucose metabolism. Decreases of 24-h circulating leptin could contribute to the weight gain during consumption of high-fat diets.

Original languageEnglish (US)
Pages (from-to)334-341
Number of pages8
Issue number2
StatePublished - 1999

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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