High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease

Jee Yon Lee; Stephanie A. Cevallos; Mariana X. Byndloss; Connor R. Tiffany; Erin E. Olsan; Brian P. Butler; Briana M. Young; Andrew W.L. Rogers; Henry Nguyen; Kyongchol Kim; Sang Woon Choi; Eunsoo Bae; Je Hee Lee; Ui Gi Min; Duk Chul Lee; Andreas J. Bäumler

doi:10.1016/j.chom.2020.06.001

High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease

Jee Yon Lee, Stephanie A. Cevallos, Mariana X. Byndloss, Connor R. Tiffany, Erin E. Olsan, Brian P. Butler, Briana M. Young, Andrew W.L. Rogers, Henry Nguyen, Kyongchol Kim, Sang Woon Choi, Eunsoo Bae, Je Hee Lee, Ui Gi Min, Duk Chul Lee, Andreas J. Bäumler

Medical Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Lee et al. find that antibiotics and high-fat diet cooperate to increase the risk for pre-IBD, characterized by low-grade mucosal inflammation and changes in the microbiota composition (dysbiosis). In a mouse model of pre-IBD, antibiotics and high-fat diet jointly impair epithelial mitochondrial function to drive dysbiosis that exacerbates mucosal inflammation.

Original language	English (US)
Pages (from-to)	273-284.e6
Journal	Cell Host and Microbe
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/j.chom.2020.06.001
State	Published - Aug 12 2020

Keywords

antibiotics
dysbiosis
high-fat diet
inflammatory bowel disease
irritable bowel syndrome
microbiota

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

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10.1016/j.chom.2020.06.001

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Lee, J. Y., Cevallos, S. A., Byndloss, M. X., Tiffany, C. R., Olsan, E. E., Butler, B. P., Young, B. M., Rogers, A. W. L., Nguyen, H., Kim, K., Choi, S. W., Bae, E., Lee, J. H., Min, U. G., Lee, D. C., & Bäumler, A. J. (2020). High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease. Cell Host and Microbe, 28(2), 273-284.e6. https://doi.org/10.1016/j.chom.2020.06.001

High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease. / Lee, Jee Yon; Cevallos, Stephanie A.; Byndloss, Mariana X.; Tiffany, Connor R.; Olsan, Erin E.; Butler, Brian P.; Young, Briana M.; Rogers, Andrew W.L.; Nguyen, Henry; Kim, Kyongchol; Choi, Sang Woon; Bae, Eunsoo; Lee, Je Hee; Min, Ui Gi; Lee, Duk Chul; Bäumler, Andreas J.

In: Cell Host and Microbe, Vol. 28, No. 2, 12.08.2020, p. 273-284.e6.

Research output: Contribution to journal › Article › peer-review

Lee, JY, Cevallos, SA, Byndloss, MX, Tiffany, CR, Olsan, EE, Butler, BP, Young, BM, Rogers, AWL, Nguyen, H, Kim, K, Choi, SW, Bae, E, Lee, JH, Min, UG, Lee, DC & Bäumler, AJ 2020, 'High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease', Cell Host and Microbe, vol. 28, no. 2, pp. 273-284.e6. https://doi.org/10.1016/j.chom.2020.06.001

Lee, Jee Yon ; Cevallos, Stephanie A. ; Byndloss, Mariana X. ; Tiffany, Connor R. ; Olsan, Erin E. ; Butler, Brian P. ; Young, Briana M. ; Rogers, Andrew W.L. ; Nguyen, Henry ; Kim, Kyongchol ; Choi, Sang Woon ; Bae, Eunsoo ; Lee, Je Hee ; Min, Ui Gi ; Lee, Duk Chul ; Bäumler, Andreas J. / High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease. In: Cell Host and Microbe. 2020 ; Vol. 28, No. 2. pp. 273-284.e6.

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abstract = "Lee et al. find that antibiotics and high-fat diet cooperate to increase the risk for pre-IBD, characterized by low-grade mucosal inflammation and changes in the microbiota composition (dysbiosis). In a mouse model of pre-IBD, antibiotics and high-fat diet jointly impair epithelial mitochondrial function to drive dysbiosis that exacerbates mucosal inflammation.",

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High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease

Abstract

Keywords

ASJC Scopus subject areas

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