Abstract
Lee et al. find that antibiotics and high-fat diet cooperate to increase the risk for pre-IBD, characterized by low-grade mucosal inflammation and changes in the microbiota composition (dysbiosis). In a mouse model of pre-IBD, antibiotics and high-fat diet jointly impair epithelial mitochondrial function to drive dysbiosis that exacerbates mucosal inflammation.
Original language | English (US) |
---|---|
Pages (from-to) | 273-284.e6 |
Journal | Cell Host and Microbe |
Volume | 28 |
Issue number | 2 |
DOIs | |
State | Published - Aug 12 2020 |
Keywords
- antibiotics
- dysbiosis
- high-fat diet
- inflammatory bowel disease
- irritable bowel syndrome
- microbiota
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Virology