High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease

Jee Yon Lee, Stephanie A. Cevallos, Mariana X. Byndloss, Connor R. Tiffany, Erin E. Olsan, Brian P. Butler, Briana M. Young, Andrew W.L. Rogers, Henry Nguyen, Kyongchol Kim, Sang Woon Choi, Eunsoo Bae, Je Hee Lee, Ui Gi Min, Duk Chul Lee, Andreas J. Bäumler

Research output: Contribution to journalArticle

Abstract

Lee et al. find that antibiotics and high-fat diet cooperate to increase the risk for pre-IBD, characterized by low-grade mucosal inflammation and changes in the microbiota composition (dysbiosis). In a mouse model of pre-IBD, antibiotics and high-fat diet jointly impair epithelial mitochondrial function to drive dysbiosis that exacerbates mucosal inflammation.

Original languageEnglish (US)
Pages (from-to)273-284.e6
JournalCell Host and Microbe
Volume28
Issue number2
DOIs
StatePublished - Aug 12 2020

Keywords

  • antibiotics
  • dysbiosis
  • high-fat diet
  • inflammatory bowel disease
  • irritable bowel syndrome
  • microbiota

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

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  • Cite this

    Lee, J. Y., Cevallos, S. A., Byndloss, M. X., Tiffany, C. R., Olsan, E. E., Butler, B. P., Young, B. M., Rogers, A. W. L., Nguyen, H., Kim, K., Choi, S. W., Bae, E., Lee, J. H., Min, U. G., Lee, D. C., & Bäumler, A. J. (2020). High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease. Cell Host and Microbe, 28(2), 273-284.e6. https://doi.org/10.1016/j.chom.2020.06.001