High efficiency, low distortion 3D diffusion tensor imaging with variable density spiral fast spin echoes (3D DW VDS RARE)

Lawrence R. Frank, Youngkyoo Jung, Souheil Inati, J. Michael Tyszka, Eric C. Wong

Research output: Contribution to journalArticle

36 Scopus citations


We present an acquisition and reconstruction method designed to acquire high resolution 3D fast spin echo diffusion tensor images while mitigating the major sources of artifacts in DTI-field distortions, eddy currents and motion. The resulting images, being 3D, are of high SNR, and being fast spin echoes, exhibit greatly reduced field distortions. This sequence utilizes variable density spiral acquisition gradients, which allow for the implementation of a self-navigation scheme by which both eddy current and motion artifacts are removed. The result is that high resolution 3D DTI images are produced without the need for eddy current compensating gradients or B0 field correction. In addition, a novel method for fast and accurate reconstruction of the non-Cartesian data is employed. Results are demonstrated in the brains of normal human volunteers.

Original languageEnglish (US)
Pages (from-to)1510-1523
Number of pages14
Issue number2
StatePublished - Jan 15 2010
Externally publishedYes



  • 3D fast spin echo
  • 3D RARE
  • Diffusion
  • Diffusion anisotropy
  • Diffusion tensor imaging
  • High angular resolution diffusion
  • Self-navigation
  • Spiral
  • Three-dimensional

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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