Abstract
In a study of 11 adult patients with acute nonlymphocytic leukemia (ANLL), infusion therapy with high-dose VP-16 and intermediate-dose cytosine arabinoside was administered. Response was assessed with reference to bone marrow aspirations performed on days 1; 12, 13, or 14; and 21 of treatment. All 7 of the patients with ANLL in relapse achieved marrow hypoplasia, and 3 of them achieved complete response. LFTs were elevated in most patients but no evidence of hepatocellular necrosis was observed. It is concluded that the value of VP-16 in ANLL may have been underestimated in the past because of inadequate dosing.
Original language | English (US) |
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Pages (from-to) | 265-266 |
Number of pages | 2 |
Journal | Cancer Chemotherapy and Pharmacology |
Volume | 20 |
Issue number | 3 |
DOIs | |
State | Published - Sep 1987 |
ASJC Scopus subject areas
- Pharmacology
- Oncology
- Cancer Research