High-dose versus standard-dose epinephrine treatment of cardiac arrest after failure of standard therapy

Bruce W. Sherman, Mark A. Munger, Garrett E. Foulke, William F. Rutherford, Edward A Panacek

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Study Objective. To assess the efficacy of high-dose epinephrine (HDE) compared with standard-dose epinephrine (SDE) in emergency department patients in cardiac arrest after SDE failed to improve asystole or ventricular fibrillation. Design. Prospective, multicenter, blinded, controlled trial. Setting. Eight academic center emergency departments. Patients. One hundred forty patients treated for cardiac arrest. Measurements and Main Results. Primary outcomes were either improvement in cardiac rhythm or return of spontaneous circulation (ROSC). Of the 140 patients enrolled, 78 received HDE and 62 received SDE. Of the 34 patients with ventricular fibrillation, 3 were resuscitated with HDE and 2 with SDE (p=0.60). Of those with asystole, ROSC occurred in 12 of HDE and 5 of SDE recipients (p=0.11). No patient had return of significant neurologic function and none survived to hospital discharge. Overall, there was no advantage to HDE after failure of SDE. Conclusion. Our results are similar to those of controlled clinical trials comparing HDE with SDE in cardiac arrest.

Original languageEnglish (US)
Pages (from-to)242-247
Number of pages6
JournalPharmacotherapy
Volume17
Issue number2
StatePublished - Mar 1997

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'High-dose versus standard-dose epinephrine treatment of cardiac arrest after failure of standard therapy'. Together they form a unique fingerprint.

Cite this